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GLICP<br />

89369<br />

essential to serially measure CD4, CD8 RTE, and TREC levels.<br />

Reference Values:<br />

CD4 ABSOLUTE<br />

Males<br />

1 month-17 years: 153-1,745 cells/mcL<br />

18-70 years: 290-1,175 cells/mcL<br />

Reference values have not been established for patients that are 70 years of age.<br />

Females<br />

1 month-17 years: 582-1,630 cells/mcL<br />

18-70 years: 457-1,766 cells/mcL<br />

Reference values have not been established for patients that are 70 years of age.<br />

CD4 RTE %<br />

Males<br />

1 month-17 years: 19.4-60.9%<br />

18-25 years: 6.4-51.0%<br />

26-55 years: 6.4-41.7%<br />

> or =56 years: 6.4-27.7%<br />

Reference values have not been established for patients that are 70 years of age.<br />

Females<br />

1 month-17 years: 25.8-68.0%<br />

18-25 years: 6.4-51.0%<br />

26-55 years: 6.4-41.7%<br />

> or =56 years: 6.4-27.7%<br />

Reference values have not been established for patients that are 70 years of age.<br />

CD4 RTE ABSOLUTE<br />

Males<br />

1 month-17 years: 50.0-926.0 cells/mcL<br />

18-70 years: 42.0-399.0 cells/mcL<br />

Reference values have not been established for patients that are 70 years of age.<br />

Females<br />

1 month-17 years: 170.0-1,007.0 cells/mcL<br />

18-70 years: 42.0-832.0 cells/mcL<br />

Reference values have not been established for patients that are 70 years of age.<br />

Clinical References: 1. Hassan J, Reen DJ: Human recent thymic emigrants--identification,<br />

expansion, and survival characteristics. J Immunol 2001;167:1970-1976 2. Kimmig S, Przybylski GK,<br />

Schmidt CA, et al: Two subsets of naïve T-helper cells with distinct T-cell receptor excision circle<br />

content in human adult peripheral blood. J Exp Med 2002;195(6):789-794 3. Junge S,<br />

Kloeckener-Gruissem B, Zufferey R, et al: Correlation between recent thymic emigrants and CD31+<br />

(PECAM-1) CD4 T-cells in normal individuals during aging and in lymphopenic children. Eur J Immunol<br />

2007;37:3270-3280 4. Dong X, Hoeltzle MV, Abraham RS: Evaluation of CD4 and CD8 recent thymic<br />

emigrants in healthy adults and children. Unpublished data 2008 5. Duszczyszyn DA, Beck JD, Antel J, et<br />

al: Altered naiveCD4 and CD8 T-cell homeostasis in patients with relapsing-remitting multiple sclerosis:<br />

thymic versus peripheral (non-thymic) mechanisms. Clin Exp Immunol 2005;143:305-313<br />

CD8 T-Cell Immune Competence Panel, Global<br />

Clinical Information: CD8 T cells play an important role in the immune response to viral or<br />

Current as of January 4, 2013 7:15 pm CST 800-533-1710 or 507-266-5700 or <strong>Mayo</strong><strong>Medical</strong><strong>Laboratories</strong>.com Page 404

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