Sorted By Test Name - Mayo Medical Laboratories

FCRYP
90453
SCRYP
86167
erythematosus, rheumatoid arthritis, and Sjogren's syndrome. It may be seen in infections such as
hepatitis, infectious mononucleosis, cytomegalovirus, and toxoplasmosis. Type II cryoglobulinemia may
also be essential, ie, occurring in the absence of underlying disease. Type III cryoglobulinemia usually
demonstrates trace levels of cryoprecipitate, may take up to 7 days to appear, and is associated with the
same disease spectrum as Type II cryoglobulinemia.
Useful For: Evaluating patients with vasculitis, glomerulonephritis, and lymphoproliferative diseases
Evaluating patients with macroglobulinemia or myeloma in whom symptoms occur with cold exposure
Interpretation: An interpretive report will be provided.
Reference Values:
Negative (positives reported as percent)
Clinical References: Kyle RA, Lust JA: Immunoglobulins and laboratory recognition of monoclonal
proteins. Section III. Myeloma and related disorders. In Neoplastic Diseases of the Blood. 3rd edition.
Edited by PH Wiernik, GP Canellos, JP Dutcher, RA Kyle. New York, Churchill Livingstone, 1996, pp
453-475
Cryptococcus Antibody, IFA (CSF)
Reference Values:
REFERENCE RANGE: or = 1:1 Antibody Detected
Diagnosis of infections of the central nervous system can
be accomplished by demonstrating the presence of intrathecallyproduced
specific antibody. However, interpretation of
results is complicated by low antibody levels found in CSF,
passive transfer of antibody from blood, and contamination
via bloody taps.
Test Performed by: Focus Diagnostics, Inc.
5785 Corporate Avenue
Cypress, CA 90630-4750
Cryptococcus Antigen Screen, Serum
Clinical Information: Cryptococcosis is an invasive fungal infection caused by Cryptococcus
neoformans. The organism has been isolated from several sites in nature, particularly weathered pigeon
droppings. Infection is usually acquired via the pulmonary route. Patients are often unaware of any
exposure history. Approximately half of the patients with symptomatic disease have a predisposing
immunosuppressive condition such as AIDS, steroid therapy, lymphoma, or sarcoidosis. Symptoms may
include fever, headache, dizziness, ataxia, somnolence, and cough. In addition to the lungs, cryptococcal
infections frequently involve the central nervous system (CNS), particularly in patients infected with HIV.
Mortality in CNS cryptococcosis may approach 25% despite antibiotic therapy. Untreated CNS
cryptococcosis is invariably fatal. Disseminated disease may affect any organ system and usually occurs
in immunosuppressed individuals.
Useful For: Aiding in the diagnosis of cryptococcosis
Interpretation: The presence of cryptococcal antigen in any body fluid (serum or cerebrospinal fluid
[CSF]) is indicative of cryptococcosis. Specimens that are positive or equivocal by EIA are automatically
reflexed to a latex agglutination (LA) test for confirmation. The LA assay will detect cryptococcal antigen
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