Sorted By Test Name - Mayo Medical Laboratories

UHSD
8582
HEPN
80609
use in the evaluation of iron deficiency Other useful applications include the detection of bleeding as a
complication of anticoagulant therapy and other medication regimens
Interpretation: Elevated levels are an indicator of the presence of blood in the feces, either from
benign or malignant causes. This test is not specific for bowel cancer.
Reference Values:
Normal:
< or =2.0 mg total hemoglobin/g feces
Marginal:
2.0-3.0 mg total hemoglobin/g feces
2.0-4.0 mg total hemoglobin/g feces*
Elevated:
>3.0 mg total hemoglobin/g feces
>4.0 mg total hemoglobin/g feces*
*Alternative reference values for persons who have ingested red meat or aspirin during any of the 3
days preceding specimen collection.
Clinical References: 1. Ahlquist DA, McGill DB, Schwartz S, et al: HemoQuant, a new quantitative
assay for fecal hemoglobin: comparison with Hemoccult. Ann Intern Med 1984;101:297-302 2. Ahlquist
DA, Wieand HS, Moertel CG, et al: Accuracy of fecal occult blood screening for colorectal neoplasia: a
prospective study using Hemoccult and HemoQuant tests. JAMA 1993;269:1262-1267 3. Harewood GC,
McConnell JP, Harrington JJ, et al: Detection of occult upper gastrointestinal bleeding: performance
differences in fecal blood tests. Mayo Clin Proc. 2002;77(1):23-28
Hemosiderin, Urine
Clinical Information: When the plasma hemoglobin level is >50 to 200 mg/dL after hemolysis, the
capacity of haptoglobin to bind hemoglobin is exceeded, and hemoglobin readily passes through the
glomeruli of the kidney. Part of the hemoglobin is absorbed by the proximal tubular cells where the
hemoglobin iron is converted to hemosiderin. When these tubular cells are later shed into the urine,
hemosiderinuria results. If all of the hemoglobin cannot be absorbed into the tubular cells, hemoglobinuria
results. Hemosiderin is found as yellow-brown granules that are free or in epithelial cells and occasionally
in casts in an acidic or neutral urine.
Useful For: Detecting hemosiderinuria, secondary to excess hemolysis, as in incompatible blood
transfusions, severe acute hemolytic anemia, or hemochromatosis
Interpretation: A positive hemosiderin indicates excess red cell destruction. Hemosiderinuria may still
be detected after hemoglobin has cleared from the urine and hemoglobin dipstick is negative.
Reference Values:
Hemosiderin: negative (reported as positive or negative)
Hemoglobin (internal specimens only): negative
RBC (internal specimens only): 0-2 rbc/hpf
Clinical References: Henry JB: Clinical Diagnosis and Management by Laboratory Methods. 18th
edition. Philadelphia, WB Saunders Company, 1991, pp 412-413
Heparin Anti-Xa Assay, Plasma
Clinical Information: Heparins are sulphated glycosaminoglycans that inactivate thrombin, factor
Xa, and several other coagulation factors; act by enhancing activity of the plasma coagulation inhibitor,
antithrombin III (AT III); prolong the activated partial thromboplastin time (APTT); of low molecular
weight heparin have minimal effect on the APTT, and require an alternative method, such as the anti-Xa
assay, to monitor therapy.
Useful For: Measuring heparin concentration: -In patients treated with low molecular weight heparin
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