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Sorted By Test Name - Mayo Medical Laboratories

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LORAZ<br />

80459<br />

89710<br />

LOX<br />

80462<br />

1 0.35-0.69 Equivocal<br />

2 0.70-3.49 Positive<br />

3 3.50-17.4 Positive<br />

4 17.5-49.9 Strongly positive<br />

5 50.0-99.9 Strongly positive<br />

6 > or =100 Strongly positive Reference values<br />

apply to all ages.<br />

Clinical References: Homburger HA: Allergic diseases. In Clinical Diagnosis and Management by<br />

Laboratory Methods. 21st edition. Edited by McPherson RA, Pincus MR. WB Saunders, Publ, New York,<br />

Chapter 53, Part VI, pp. 961-971, 2007<br />

Lorazepam (Ativan), Serum<br />

Reference Values:<br />

Reference Range: 50.0-240.0 ng/mL<br />

<strong>Test</strong> Performed <strong>By</strong>: Medtox <strong>Laboratories</strong>, Inc.<br />

402 W. County Road D<br />

St. Paul, MN 55112<br />

Low-Grade Fibromyxoid Sarcoma, 16p11 (FUS or TLS)<br />

Rearrangement, FISH, Tissue<br />

Clinical Information: Low-grade fibromyxoid sarcoma (LGFMS) is a rare malignant soft tissue<br />

tumor characterized by a bland fibroblastic spindle cell proliferation arranged in alternating fibrous and<br />

myxoid areas, with or without giant collagen rosettes. These tumors are characterized by the chromosome<br />

translocation t(7;16)(q33-34;p11), which results in the fusion of FUS (also called TLS) on chromosome<br />

16 to CREB3L2 (also called BBF2H7) on chromosome 7. Greater than 70% of LGFMS are<br />

cytogenetically characterized by this translocation. In rare cases, a variant t(11;16) (p11;p11) has been<br />

described in which FUS is fused to CREB3L1 (OASIS), a gene structurally related to CREB3L2. <strong>Test</strong>ing<br />

of FUS locus rearrangement should be concomitant with histologic evaluation, and positive results may<br />

support the diagnosis of LGFMS.<br />

Useful For: Aiding in the diagnosis of low-grade fibromyxoid sarcoma when used in conjunction with<br />

an anatomic pathology consultation<br />

Interpretation: A neoplastic clone is detected when the percent of cells with an abnormality exceeds<br />

the normal cutoff for the FUS probe set. A positive result is consistent with the diagnosis of low-grade<br />

fibromyxoid sarcoma (LGFMS). A negative result suggests that a FUS gene rearrangement is not present,<br />

but does not exclude the diagnosis of LGFMS.<br />

Reference Values:<br />

An interpretative report will be provided.<br />

Loxapine (Loxitaner) and 8-Hydroxyloxapine<br />

Reference Values:<br />

Loxapine:<br />

Reference Range: 5.0 - 30.0 ng/mL<br />

Current as of January 4, 2013 7:15 pm CST 800-533-1710 or 507-266-5700 or <strong>Mayo</strong><strong>Medical</strong><strong>Laboratories</strong>.com Page 1121

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