Sorted By Test Name - Mayo Medical Laboratories

FRUCT
81610
FROS
81164
GFDMS
protein in Friedreichâ€s ataxia patients and carriers. Mol Genet Metab 2008;94:491-497 2. Babady NE,
Carelle N, Wells RD, et al: Advancements in the pathophysiology of Friedreich ataxia and new prospects
for treatments. Mol Genet Metab 2007;92:23-35 3. Boehm T, Scheiber-Mojdehkar B, Kluge B, et al:
Variations of frataxin protein levels in normal individuals. Neurol Sci 2010 May 27, PubMed: 20506029
Fructosamine, Serum
Clinical Information: Fructosamine is a general term, which applies to any glycated protein. It is
formed by the nonenzymatic reaction of glucose with the a- and e-amino groups of proteins to form
intermediate compounds called aldimines. These aldimines may dissociate or undergo an Amadori
rearrangement to form stable ketoamines called fructosamines. This nonenzymatic glycation of specific
proteins in vivo is proportional to the prevailing glucose concentration during the lifetime of the protein.
Therefore, glycated protein measurements in the diabetic patient is felt to be a better monitor of long-term
glycemic control than individual or sporadic glucose determinations. The best known of these proteins is
glycated hemoglobin which is often measured as hemoglobin A1C, and reflects glycemic control over the
past 6 to 8 weeks. In recognition of the need for a measurement which reflects intermediate-term glycemic
control and was easily automated, a nonspecific test, termed fructosamine, was developed. Since albumin
is the most abundant serum protein, it accounts for 80% of the gylcated serum proteins, and thus, a high
proportion of the fructosamine. Although a large portion of the color generated in the reaction is
contributed by glycated albumin, the method will measure all proteins, each with a different half-life and
different levels of glycation.
Useful For: Assessing intermediate-term glycemic control
Interpretation: In general, fructosamine reflect glycemic control in diabetic patients over the previous
2 to 3 weeks. High values indicate poor control.
Reference Values:
200-285 mcmol/L
Clinical References: 1. Tietz Textbook of Clinical Chemistry, Edited by Burtis and Ashwood.
Philadelphia, WB Saunders Company, 1999 2. Austin GE, Mullins RH, Morin LG: Non-enzymatic
glycation of individual plasma proteins in normoglycemic and hyperglycemic patients. Clin Chem
1987;33:2220-2224 3. Schleicher ED, Mayer R, Wagner EM, Gerbitz KD: Is serum fructosamine assay
specific for determination of glycated serum protein? Clin Chem 1988;34:320-323
Fructose, Semen or Seminal Plasma
Clinical Information: Fructose is produced in the male reproductive tract by the seminal vesicles and
is released into the semen during ejaculation. Fructose is the energy source for sperm motility.
Useful For: Fructose testing should be considered for patients with azoospermia and low volume
ejaculates to establish the origin of the azoospermia.
Interpretation: A positive (indicated by color change) fructose is considered normal. A semen
specimen that contains no sperm (azoospermia) and is fructose negative may indicate an absence of the
seminal vesicles, absence of the vas deferens in the area of the seminal vesicles, or an obstruction at the
level of the seminal vesicles.
Reference Values:
Positive
Clinical References: Lipshultz LI, Howards SS: Infertility in the Male. 2nd edition. Edited by DK
Marshall. St. Louis, MO, Mosby-Year Book, Inc., 1991, pp 133-135, 194, 209
FTCD Gene, Full Gene Analysis
89900
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