Sorted By Test Name - Mayo Medical Laboratories

GASCA
83023
FSAF
91665
FSAGE
91992
Saccharomyces cerevisiae Antibody, IgG, Serum
Clinical Information: Inflammatory bowel disease (IBD) refers to 2 diseases, ulcerative colitis (UC)
and Crohn's disease (CD), which produce inflammation of the large or small intestines.(1) The diagnoses
of both diseases are based on clinical features, radiographic findings, colonoscopy, mucosal biopsy
histology, and, in some cases, operative findings and resected bowel pathology and histology. Patients
with IBD have also been shown to have antibodies in serum that help distinguish between CD and UC.(2)
Patients with UC often have measurable neutrophil-specific antibodies (NSA) that react with as yet
uncharacterized target antigens in human neutrophils; whereas patients with CD often have measurable
antibodies of the IgA and/or IgG isotypes that react with cell wall mannan of Saccharomyces cerevisiae
strain Su 1.
Useful For: Helping clinicians distinguish between ulcerative colitis and Crohn's disease in patients
suspected of having inflammatory bowel disease
Interpretation: In IBDP/81443 Inflammatory Bowel Disease Serology Panel, Serum, ASCA and
neutrophil-specific antibodies (NSA) are measured. The finding of NSA with normal levels of IgA and
IgG ASCA is consistent with the diagnosis of ulcerative colitis (UC); the finding of negative NSA with
elevated IgA and IgG ASCA is consistent with Crohn's disease (CD). NSA are detectable in
approximately 50% of patients with UC. Elevated levels of either IgA or IgG ASCA occur in
approximately 55% of patients with CD. Elevated levels of both IgA and IgG ASCA occur in
approximately 40% of patients with CD. Employed together, the tests for NSA and ASCA have the
following positive predictive values (PPV) for UC and CD, respectively:(2) -NSA positive with normal
levels of IgA and IgG ASCA, PPV of 91% -NSA negative with elevated levels of IgA and IgG ASCA,
PPV of 90%
Reference Values:
Negative: 0.0-20.0 U
Equivocal: 20.1-24.9 U
Weakly positive: 25.0-34.9 U
Positive: > or =35.0 U
Clinical References: 1. Rose, Noel, and Mackay Ian. The Autoimmune Diseases: Inflammatory
Bowel Diseases. New York, NY, Elsevier Academic Press, 2008 2. Sandborn WJ, Loftus EV Jr,
Homburger HA, et al: Evaluation of serological disease markers in a population-based cohort of patients
with ulcerative colitis and Crohn's disease. Inflamm Bowel Dis 2001 Aug;7(3):192-201
Safflower IgE
Interpretation: Conventional RAST Scoring Guide Class IgE (kU/L Comment 0 or = 17.5 Strong Positive
Reference Values: