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FHPEP
57369
ingestion of oxalate, ascorbic acid, or ethylene glycol; or pyridoxine deficiency, and may respond to
appropriate therapy. A diagnostic workup in an individual with hyperoxaluria demonstrates increased
concentration of oxalate in urinary metabolite screening. If either glycolate or glycerate is present, a
primary hyperoxaluria is indicated. Additional analyses can include molecular testing for PH1 or PH2.
Useful For: Distinguishing between primary and secondary hyperoxaluria Distinguishing between type
I and type II primary hyperoxaluria
Interpretation: Increased concentrations of oxalate and glycolate indicate type I hyperoxaluria.
Increased concentrations of oxalate and glycerate indicate type II hyperoxaluria. Increased concentrations
of oxalate with normal concentrations of glycolate and glycerate indicate secondary hyperoxaluria.
Reference Values:
GLYCOLATE
0-31 days: 0-57 mg/g creatinine
1-5 months: 0-54 mg/g creatinine
6-12 months: 0-60 mg/g creatinine
1-5 years: 0-89 mg/g creatinine
> or =6 years: 0-78 mg/g creatinine
GLYCERATE
0-31 days: 0-38 mg/g creatinine
1-5 months: 0-71 mg/g creatinine
6-12 months: 0-56 mg/g creatinine
1-5 years: 0-17 mg/g creatinine
> or =6 years: 0-8 mg/g creatinine
OXALATE
0-31 days: 0-301 mg/g creatinine
1-5 months: 0-398 mg/g creatinine
6-12 months: 0-280 mg/g creatinine
1-5 years: 0-128 mg/g creatinine
6-10 years: 0-72 mg/g creatinine
> or =11 years: 0-56 mg/g creatinine
GLYOXYLATE
0-31 days: 0.0-7.9 mg/g creatinine
1-5 months: 0.0-11.4 mg/g creatinine
6-12 months: 0.0-5.5 mg/g creatinine
1-5 years: 0.0-3.9 mg/g creatinine
> or =6 years: 0.0-2.9 mg/g creatinine
Clinical References: 1. Monico CG, Persson M, Ford GC, et al: Potential mechanisms of marked
hyperoxaluria not due to primary hyperoxaluria I or II. Kidney Int 2002;62:392-400 2. Danpure CJ:
Primary hyperoxaluria. In The Metabolic Bases of Inherited Disease. 8th edition. Edited by CR Scriver,
AL Beaudet, WS Sly, et al. New York, McGraw-Hill Book Company, 2001, pp 3323-3367 3. Byrd DJ,
Latta K: Hyperoxaluria. In Physicianâ€s Guide to the Laboratory Diagnosis of Metabolic Disease.
Edited by N Blau, ED Chapman. Hall Medical, 1996, pp 377-390 4. Fraser AD: Importance of glycolic
acid analysis in ethylene glycol poisoning. Clin Chem 1998;44(8):1769
Hypersensitivity Pneumonitis Extended Panel (Farmer's Lung
Panel)
Reference Values:
Procedure Units Ref Interval
Aspergillus fumigatus #1 Antibody None Detected
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