Sorted By Test Name - Mayo Medical Laboratories

EAG
80510
HBGCD
83626
Hepatitis Be Antigen, Serum
Clinical Information: Hepatitis Be antigen (HBeAg) is found in the early phase of hepatitis B
infection soon after hepatitis Bs antigen becomes detectable. Serum levels of both antigens rise rapidly
during the period of viral replication. The presence of HBeAg correlates with hepatitis B virus (HBV)
infectivity, the number of viral Dane particles, the presence of core antigen in the nucleus of the
hepatocyte, and presence of viral DNA polymerase in serum. In HBV carriers and patients with chronic
hepatitis B, positive HBeAg results usually indicate presence of active HBV replication and high
infectivity. A negative HBeAg result indicates very minimal or lack of HBV replication. See Viral
Hepatitis Serologic Profile and HBV Infection-Diagnostic Approach and Management Algorithm in
Special Instructions. In addition, see The Laboratory Approach to the Diagnosis and Monitoring of
Hepatitis B Infection in Publications.
Useful For: Determining infectivity of hepatitis B virus (HBV) carriers Monitoring infection status of
chronically HBV-infected patients Monitoring serologic response of chronically HBV-infected patients
who are receiving antiviral therapy
Interpretation: Presence of hepatitis Be (HBe) antigen and absence of HBe antibody usually indicate
active hepatitis B virus (HBV) replication and high infectivity. Absence of HBe antigen with appearance
of HBe antibody is consistent with resolution of HBV infectivity.
Reference Values:
Negative
See Viral Hepatitis Serologic Profiles in Special Instructions.
Clinical References: 1. Servoss JC, Friedman LS: Serologic and molecular diagnosis of hepatitis B
virus. Clin Liver Dis 2004;8:267-281 2. Badur S, Akgun A: Diagnosis of hepatitis B infections and
monitoring of treatment. J Clin Virol 2001 Jun;21(3):229-237
Hepatitis Bs Antigen (HBsAg) for Cadaveric or Hemolyzed
Specimens, Serum
Clinical Information: Hepatitis B virus (HBV) is endemic throughout the world. The infection is
spread primarily through percutaneous contact with infected blood products (eg, blood transfusion,
sharing of needles by intravenous drug addicts). The virus is also found in various human body fluids, and
it is known to be spread through oral and genital contacts. HBV can be transmitted from mother to child
during delivery through contact with blood and vaginal secretions, but it is not commonly transmitted
transplacentally. Hepatitis B surface antigen (HBsAg) is the first serologic marker appearing in the serum
at 6 to 16 weeks following HBV infection. In acute infection, HBsAg usually disappears in 1 to 2 months
after the onset of symptoms. Persistence of HBsAg for >6 months indicates development of either a
chronic carrier or chronic HBV infection.
Useful For: Testing cadaveric and hemolyzed blood specimens for hepatitis B surface antigen;
FDA-licensed for use with hemolyzed specimens Diagnosis of acute, recent (