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ACM<br />

8698<br />

FACTO<br />

90247<br />

1 0.35-0.69 Equivocal<br />

2 0.70-3.49 Positive<br />

3 3.50-17.4 Positive<br />

4 17.5-49.9 Strongly positive<br />

5 50.0-99.9 Strongly positive<br />

6 > or =100 Strongly positive Reference values<br />

apply to all ages.<br />

Clinical References: Homburger HA: Allergic diseases. In Clinical Diagnosis and Management by<br />

Laboratory Methods. 21st edition. Edited by McPherson RA, Pincus MR. WB Saunders, Publ, New York,<br />

Chapter 53, Part VI, pp. 961-971, 2007<br />

Acetaminophen, Serum<br />

Clinical Information: Acetaminophen (found in Anacin-3, Comtrex, Contac, Datril, Dristan,<br />

Excedrin, Nyquil, Sinutab, Tempera, Tylenol, Vanquish, and many others) is an analgesic, antipyretic<br />

drug lacking significant anti-inflammatory activity. It is metabolized by the liver with a normal<br />

elimination half-life of or =120<br />

mcg/mL. The level at which toxicity occurs decreases with increasing half-life until it is encountered at<br />

values as low as 50 mcg/mL when the half-life reaches 12 hours. For half-life determination, draw 2<br />

specimens at least 4 hours apart and note the exact time of each draw. Half-life can be calculated from the<br />

concentrations and the time interval.<br />

Reference Values:<br />

Therapeutic concentration: or =120 mcg/mL<br />

Half-life: 4 hours<br />

The toxic level is dependent on half-life. When the half-life is 4 hours, hepatotoxicity generally is not<br />

seen until the concentration is > or =120 mcg/mL. The level at which toxicity occurs decreases with<br />

increasing half-lives until it is encountered at values as low as 50 mcg/mL when the half-life reaches 12<br />

hours.<br />

Clinical References: Rumack BH, Peterson RG: Acetaminophen overdose: incidence, diagnosis,<br />

and management in 416 patients. Pediatrics Nov 1978;62:898-903<br />

Acetoacetate, Serum or Plasma<br />

Reference Values:<br />

Reporting limit determined each analysis.<br />

Current as of January 4, 2013 7:15 pm CST 800-533-1710 or 507-266-5700 or <strong>Mayo</strong><strong>Medical</strong><strong>Laboratories</strong>.com Page 40

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