Sorted By Test Name - Mayo Medical Laboratories

MEPHS
83778
FMERC
91120
HGOM
82755
TEST PERFORMED BY
MEDTOX LABORATORIES, INC.
402 W. COUNTY ROAD D
ST. PAUL, MN 55112
Mephobarbital and Phenobarbital, Serum
Clinical Information: Mephobarbital is an orally administered, methylated barbiturate used for the
treatment of epilepsy.(1,2) It is demethylated by hepatic microsomal enzymes to generate its major
metabolite, phenobarbital. During long-term use, most of mephobarbital's activity can be attributed to the
accumulation of phenobarbital. Consequently, mephobarbital's pharmacological properties, toxicity, and
clinical uses are the same as phenobarbital's.(1,2) The use of mephobarbital is uncommon as it offers no
significant advantage over phenobarbital alone.(1,2)
Useful For: Monitoring of mephobarbital and phenobarbital therapy
Interpretation: The therapeutic range for mephobarbital is 1.0 to 7.0 mcg/mL. In children, the
therapeutic range for phenobarbital is 15.0 to 30.0 mcg/mL; in adults the therapeutic range is 20.0 to 40.0
mcg/mL.
Reference Values:
MEPHOBARBITAL
Therapeutic range: 1.0-7.0 mcg/mL
Toxic concentration: > or =15.0 mcg/mL
PHENOBARBITAL
Therapeutic range
Children: 15.0-30.0 mcg/mL
Adults: 20.0-40.0 mcg/mL
Toxic concentration: > or =60.0 mcg/mL
Concentration at which toxicity occurs varies and should be interpreted in light of clinical situation.
Clinical References: 1. Teitz Textbook of Clinical Chemistry and Molecular Diagnostics. 4th
edition. Edited by CA Burtis, ER Ashwood, DE Bruns. St. Louis, MO, Elsvier Saunders, 2006, pp 1091 2.
Disposition of Toxic Drugs and Chemicals in Man. 7th edition. Edited by RC Baselt. Foster City, CA,
Biomedical Publications, 2004, pp 1254
Mercaptopurine (6-MP, Purinethol)
Reference Values:
Mercaptopurine may be administered as an antineoplastic or
may be present as a metabolite of the immunosuppressant drug
azathioprine. Therapeutic and toxic ranges have not been
established. Usual therapeutic doses of either mercaptopurine
or azathioprine produce 6-mercaptopurine serum concentrations of
less than 1000 ng/mL.
Test Performed By:
Medtox Laboratories, Inc.
402 W. County Road D
St. Paul, MN 55112
Mercury for Occupational Monitoring, Urine
Clinical Information: Mercury (Hg), a well-known toxin, is essentially nontoxic in its elemental
form. However, once it is chemically modified to the ionized, inorganic species, Hg(++), it becomes
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