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FGHBS<br />

91764<br />

FGHB<br />

91702<br />

GANC<br />

80140<br />

Gamma-Hydroxybutyric Acid (GHB), Serum-Forensic<br />

Reference Values:<br />

Reference Range: Negative (ug/mL)<br />

Gamma-Hydroxybutyric Acid, Serum<br />

The clinical effects of Gamma-Hydroxybutyric Acid have been associated with the following<br />

concentrations:<br />

Wakefulness: 260 ug/mL<br />

<strong>Test</strong> Performed by: Medtox <strong>Laboratories</strong>, Inc.<br />

402 W. County Road D<br />

St. Paul, MN 55112<br />

Gamma-Hydroxybutyric Acid (GHB), Urine-Forensic<br />

Reference Values:<br />

Reporting Limit: 2.0 ug/mL<br />

Reference Range: Negative<br />

<strong>Test</strong> Performed <strong>By</strong>: Medtox <strong>Laboratories</strong>, Inc.<br />

402 W. County Road D<br />

St. Paul, MN 55112<br />

Ganciclovir, Serum<br />

Clinical Information: Ganciclovir, an analog of acylcovir, demonstrates inhibitory action against<br />

some viruses including herpes virus, cytomegalovirus, and HIV. Therapeutic ranges have not been<br />

well-established for ganciclovir; current ranges are based on typical values seen during ganciclovir<br />

therapy and do not correlate well to toxicity or outcome. Monitoring of ganciclovir serum concentrations<br />

may be most useful in guiding therapy in patients with renal dysfunction. Myelosuppression is the major<br />

dose-limiting side effect of ganciclovir. Valcyte (valganciclovir) is an oral pro-drug of ganciclovir ester. It<br />

is immediately converted to ganciclovir once it enters the bloodstream. The oral dose is designed to<br />

deliver ganciclovir equivalent to intravenous ganciclovir at 5 mg/kg.<br />

Useful For: Monitoring patients on ganciclovir<br />

Interpretation: Serum concentrations of ganciclovir do not correlate well to toxicity or efficacy. Peak<br />

and trough levels provided are representative of typical serum concentrations seen during therapy, but<br />

individual values must be interpreted in conjunction with the clinical status of the individual patient and<br />

the specific characteristics of the infecting microorganism.<br />

Reference Values:<br />

Trough: 1.0-3.0 mcg/mL<br />

Peak: 3.0-12.5 mcg/mL<br />

Clinical References: 1. Perrottet N, Decosterd LA, Meylan P, et al: Valganciclovir in adult solid<br />

organ transplant recipients: paharmacokinetic and pharmacodynamic characteristics and clinical<br />

interpretation of plasma concentration measurements. Clin Pharmacokinet 2009;48(6):399-418 2. Uges D:<br />

Therapeutic and toxic drug concentrations, The International Association of Forensic Toxicologists. Dec<br />

2009. Retrieved 12/09; Available from URL: www.tiaft.org<br />

Current as of January 4, 2013 7:15 pm CST 800-533-1710 or 507-266-5700 or <strong>Mayo</strong><strong>Medical</strong><strong>Laboratories</strong>.com Page 799

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