Sorted By Test Name - Mayo Medical Laboratories

PALB
9005
FPRGA
57110
17PRN
88646
Reference Values:
An interpretive report will be provided.
Clinical References: 1. Buiting K: Prader-Willi syndrome and Angelman syndrome. Am J of Med
Genet Part C 2010;154C:365-376 2. Williams CA, Beaudet AL, Clayton-Smith J, et al: Angelman
syndrome 2005: updated consensus for diagnostic criteria. AM J Med Genet 2006:140A:413-418 3.
Gunay-Aygun M, Schwartz S, Heeger S, et al: The changing purpose of Prader-Willi syndrome clinical
diagnostic criteria and proposed revised criteria. Pediatrics 2001;108(5):e92 4. Nygren AOH, Ameziane
N, Duarte HM, et al: Methylation-specific MLPA (MS-MLPA): simultaneous detection of CpG
methylation and copy number changes of up to 40 sequences. Nucleic Acids Res 2005;33:128 5. Procter
M, Chou L, Tang W, et al: Molecular diagnosis of Prader-Willi and Angelman syndromes by
methylation-specific multiplex ligation-dependent probe amplification. Clin Chem 2006;52:1276-1283
Prealbumin (PAB), Serum
Clinical Information: Prealbumin is synthesized in the liver and acts as a binding protein for
thyroxine and retinol-binding protein. The serum concentration of prealbumin reflects the synthesis
capacity of the liver and is markedly diminished in malnutrition and other conditions. Due to its short
half-life of approximately 2 days, prealbumin can be used for monitoring the nutritional status and
efficacy of parenteral nutrition.
Useful For: Assessing nutritional status, especially in monitoring the response to nutritional support in
the acutely ill patient
Interpretation: Values of 0 ng/dL to 5 mg/dL, 5 mg/dL to 10 mg/dL, and 10 mg/dL to 15 mg/dL
indicate severe, moderate, and mild protein depletion.
Reference Values:
19-38 mg/dL
Clinical References: 1. Haider M, Haider SQ: Assessment of protein-calorie malnutrition. Clin
Chem 1984;30:1286-1299 2. Grant JP, Custer PB, Thurlow J: Current techniques of nutritional
assessment. Surg Clin North Am 1981;61:437-463 3. Bernstein LH, Leukhardt-Fairfield CJ, Pleban W, et
al: Usefulness of data on albumin and prealbumin concentrations in determining effectiveness of
nutritional support. Clin Chem 1989;35:271-274 4. Kanakoudi F, Drossou V, Tzimouli V, et al: Serum
concentrations of 10 acute-phase proteins in healthy term and pre-term infants from birth to age 6 months.
Clin Chem 1995;41:605-608
Pregabalin (Lyrica)
Reference Values:
Therapeutic and toxic ranges have not been established.
Expected steady state pregabalin concentrations in patients
taking recommended daily dosages: up to 10 ug/mL.
Test Performed By: Medtox Laboratories
402 W. County Road D
St. Paul, MN 55112
Pregnenolone and 17-Hydroxypregnenolone
Clinical Information: Congenital adrenal hyperplasia (CAH) is caused by inherited defects in steroid
biosynthesis. Deficiencies in several enzymes cause CAH including 21-hydroxylase (CYP21A2
mutations; 90% of cases), 11-hydroxylase (CYP11A1 mutations; 5%-8%), 3-beta-hydroxy dehydrogenase
(HSD3B2 mutations;