Sorted By Test Name - Mayo Medical Laboratories

HPFH
8270
SFMON
60205
hemoglobin F concentration is often slightly increased. Higher concentrations of hemoglobin F occur in
hemoglobin S/beta O-thalassemia, in patients who are doubly heterozygous for the hemoglobin S gene,
and in patients who have a gene for hereditary persistence of fetal hemoglobin (HPFH). These disorders
may be differentiated by family studies or by flow cytometry studies for fetal hemoglobin, which reveals
uniform intraerythrocytic distribution of hemoglobin F in HPFH and nonuniform distribution in
hemoglobin S/beta-thalassemia. The electrophoretic finding of small quantities of hemoglobin A in a
patient who has mostly hemoglobin S and a moderate increase in hemoglobin F is strong evidence of
hemoglobin S/beta zero thalassemia (if the patient has not had a transfusion).
Useful For: Quantitating the percent of fetal hemoglobin present Assisting in the diagnosis of disorders
with elevated levels of fetal hemoglobin
Interpretation: See Clinical Information and Reference Values.
Reference Values:
1-30 days: 22.8-92.0%
1-2 months: 7.6-89.8%
3-5 months: 1.6-42.2%
6-8 months: 0.0-16.7%
9-12 months: 0.0-10.5%
13-17 months: 0.0-7.9%
18-23 months: 0.0-6.3%
> or =24 months: 0.0-0.9%
Clinical References: Fairbanks VF, Klee GG: Biochemical aspects of hematology. In Tietz
Textbook of Clinical Chemistry. 3rd edition. Edited by CA Burtis, ER Ashwood, Philadelphia, WB
Saunders Company, 1999, pp 1657-1669
Hemoglobin F, Red Cell Distribution, Blood
Clinical Information: In the common form of the genetic trait hereditary persistence of fetal
hemoglobin (HPFH), all of the erythrocytes contain hemoglobin F (Hb F). More than 75% of the
hemoglobin of the newborn is Hb F; it diminishes over a period of several months to adult levels,
becoming