Sorted By Test Name - Mayo Medical Laboratories

KETAU
89443
FKEBS
91887
FKETO
Test Performed By: Focus Diagnostics, Inc
5785 Corporate Avenue
Cypress, CA 90630-4750
Ketamine and Metabolite Confirmation, Urine
Clinical Information: Ketamine has been used in the United States as an anesthetic induction agent
since 1972. The drug acts by noncompetitive antagonism of the N-methyl-D-aspartate (NMDA)-type
glutamate receptors.(1,2) Ketamine has become a popular street drug because of its hallucinogenic
effects.(3) Ketamine has a half-life of 3 to 4 hours, and is metabolized to norketamine.(3) The effects
from ketamine last from 1 to 5 hours, and ketamine and/or norketamine can be detected in the urine for a
period of 1 to 2 days following use.(4)
Useful For: Detection and confirmation of ketamine use
Interpretation: The presence of ketamine and/or norketamine >25 ng/mL is a strong indicator that the
patient has used ketamine.
Reference Values:
Negative
Clinical References: 1. Ujhelyi MR, Robert S, Cummings DM, et al: Influence of digoxin immune
Fab therapy and renal dysfunction on the disposition of total and free digoxin. Ann Intern Med
1993;119:273-277 2. Goodman & Gilman's: The Pharmacological Basis of Therapeutics. 10th edition.
New York. McGraw-Hill Book Company, 2001 3. Baselt RC. Disposition of Toxic Drugs and Chemicals
in Man. 7th edition. Foster City, CA. Biomedical Publications, 2004 pp 1254 4. Mozayani A:
Ketamine-Effects on human performance and behavior. Forensic Sci Rev 2002;14:123-131
Ketamine and Metabolite Screen/Confirmation, Serum/Plasma
Reference Values:
Reporting limit determined each analysis
Units: ng/mL
Ketamine:
Synonym(s): Ketalar
Reported levels during anesthesia: 500-6500 ng/mL
Norketamine:
Synonym(s): Ketamine Metabolite
The intravenous administration of 2 mg/kg of Ketamine followed by
continuous infusion of 41 mcg/kg/minute produced an average steadystate
plasma concentration of 2200 ng Ketamine/mL and an average
peak Norketamine level of 1050 ng/mL which occurred near the end
of the 3 hour infusion.
Test Performed by: NMS Labs
3701 Welsh Road
P.O. Box 433A
Willow Grove, PA 19090-0437
Ketoconazole, Serum/Plasma
90317
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