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nutritional status, especially those who appear at risk and who also are being given insulin for
hyperglycemia
Interpretation: Values for thiamin diphosphate 99%) of cervical epithelial neoplasms are the result of HPV
infection. “High-riskâ€â€ HPV types (16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, and 68) can
result in both low-grade squamous intraepithelial lesion (LSIL) and high-grade squamous intraepithelial
lesion (HSIL), as well as invasive carcinoma.(1,2) Patients with both negative cytology and negative HPV
have been shown to be at extremely low risk for cervical neoplasia.(1,2) For women 30 years and older
who have received a negative Pap test and concurrent negative HPV result, the American Cancer Society
(ACS) and American College of Obstetricians and Gynecologists (ACOG) recommendations for cervical
screening state that physicians may lengthen the screening interval to 3 years when using the combined
tests. Patients deemed to be at high risk by the clinician should still be screened more frequently. The
presence of high-risk HPV types in cervical specimens identifies a subgroup of patients with a greater
likelihood of having a high-grade squamous intraepithelial lesion. Current guidelines for follow up of a
cytology-negative/HPV-positive patient recommend repeat HPV testing in 12 months.(2)
Useful For: Detection of cervical carcinoma or intraepithelial lesions and the presence or absence of
high-risk HPV in women over age 30 at risk for cervical neoplasia
Interpretation: The cytology report on gynecologic specimens is an estimate of the nature of the
abnormality using the Bethesda nomenclature.(3) Specimen adequacy is characterized as: -Satisfactory for
evaluation (with quality indicators if applicable) -Unsatisfactory for evaluation, further subdivided as
follows: -Specimen processed and examined but unsatisfactory for evaluation of epithelial abnormality
because of inadequate cellularity, obscuring blood or inflammation, etc. -Specimen rejected because of a
broken slide, unlabeled specimen, etc. The diagnostic interpretation may include: -Negative for
intraepithelial lesion or malignancy (NIL) -Atypical squamous cells of undetermined significance
(ASCUS) characterized as either: -Atypical squamous cells of undetermined significance -Atypical
squamous cells, cannot exclude high-grade intraepithelial lesion -Low-grade squamous intraepithelial
lesion (LSIL), which includes mild squamous dysplasia (cervical intraepithelial neoplasia I [CINI]) and
koilocytotic changes consistent with HPV effect -High-grade squamous intraepithelial lesion (HSIL),
which includes moderate squamous dysplasia (CINII), severe squamous dysplasia (CINIII), and squamous
carcinoma in situ (CINIII) -Atypical glandular cells: patients with this diagnosis are at increased risk for a
clinically significant lesion, including adenocarcinoma in situ, high-grade squamous intraepithelial lesion,
invasive cervical carcinoma, or endometrial carcinoma, and should have appropriate clinical follow-up
that may include gynecologic examination, colposcopy, or biopsy. HPV: A positive HPV test result
indicates the presence of 1 or more of the high-risk HPV types (16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58,
59, or 68).
Reference Values:
ThinPrep PAP Test Diagnostic:
Satisfactory for evaluation. Negative for intraepithelial lesion or malignancy.
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