Sorted By Test Name - Mayo Medical Laboratories

FEU
8571
FET
8350
Reference Values:
IRON
Males: 50-150 mcg/dL
Females: 35-145 mcg/dL
TOTAL BINDING CAPACITY
250-400 mcg/dL
PERCENT SATURATION
14-50%
Clinical References: 1. Tietz Textbook of Clinical Chemistry. Edited by CA Burtis, ER Ashwood.
Philadelphia, WB Saunders Company. 1999 2. Fairbanks VF, Baldus WP: Iron overload. In Hematology.
Fourth edition. Edited by WJ Williams, AJ Erslev, MA Lichtman. New York, McGraw-Hill Book
Company, 1990, pp 482-505
Iron, 24 Hour, Urine
Clinical Information: Iron is an essential element, serving as an enzyme cofactor and to facilitate
oxygen transport. Iron is cleared primarily by biliary excretion via the feces and secondarily by renal
clearance, which is a relatively minor route of clearance. Excessive accumulation of iron in iron-overload
diseases leads to higher than normal urine concentration of iron, known as hemosiderinuria.
Useful For: Diagnosis of hemochromatosis, hemolytic anemia, paroxysmal nocturnal hemoglobinemia,
and impaired biliary clearance
Interpretation: Normal excretion of iron occurs at the rate of approximately 100 mcg/day to 300
mcg/day. In the event that dietary iron is below minimum daily requirements ( or =16 years: 100-300 mcg/specimen
Clinical References: 1. Gurzau ES, Neagu C, Gurzau AE: Essential metals case study on iron.
Ecotoxicol Environ Saf 2003;56:190-200 2. Ludwig J, Batts KP, Moyer TP, Poterucha JJ: Advances in
liver biopsy diagnosis. Mayo Clin Proc 1994;69:677-678
Iron, Liver Tissue
Clinical Information: Hemosiderosis is the condition of excessive iron accumulation in tissues. Liver
is the first organ affected in iron-overload diseases. Transient increases in iron first appear in Kupffer
cells. This finding is commonly related to sideroblastic anemia, excessive iron consumption, or chronic
alcohol ingestion. Persistent hemosiderosis, as seen in hemochromatosis, causes iron accumulation in
hepatocytes, and is usually concentrated in biliary cells. Hereditary hemochromatosis is an autosomal
recessive disease with estimated prevalence in the population of 2 in 1,000 in Caucasians, with lower
incidence in other races. The gene responsible for hereditary hemochromatosis (HFE) is located on
chromosome 6; the majority of hereditary hemochromatosis patients have mutations in this HFE gene.
Hereditary hemochromatosis is characterized by an accelerated rate of intestinal iron absorption and
progressive iron deposition in various tissues that typically begins to be expressed in the third to fifth
decades of life, but may occur in children. The most common presentation is hepatic cirrhosis in
combination with hypopituitarism, cardiomyopathy, diabetes, arthritis, or hyperpigmentation. Because of
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