Sorted By Test Name - Mayo Medical Laboratories

FFRBC
57329
FOL
9198
interactions to address potential compliance issues.
Reference Values:
Negative
Cutoff concentration: 10 pg/mL
Values for normal patients not taking fluticasone propionate should be less than the cutoff concentration
(detection limit).
Clinical References: 1. Pearce RE, Leeder JS, Kearns GL: Biotransformation of fluticasone: in vitro
characterization. Drug Metab Dispos 2006;34:1035-1040 2. Paton J, Jardine E, McNeill E, et al: Adrenal
responses to low dose synthetic ACTH (Synacthen) in children receiving high dose inhaled fluticasone.
Arch Dis Child 2006;91:808-813 3. Callejas SL, Biddlecombe RA, Jones AE, et al: Determination of the
glucocorticoid fluticasone propionate in plasma by automated solid-phase extraction and liquid
chromatography-tandem mass spectrometry. J Chromatogr B Biomed Sci Appl 1998;718:243-250 4.
Bender BG, Bartlett SJ, Rand CS, et al: Impact of interview mode on accuracy of child and parent report
of adherence with asthma-controller medication. Pediatrics. 2007;120:e471-477 5. National Asthma
Education and Prevention Program: Expert Panel Report 3 (EPR-3):Guidelines for the Diagnosis and
Management of Asthma -Summary Report 2007. J Allergy Clin Immunol. 2007 Nov;120(5
Suppl):S94-138
Folate, RBC
Reference Values:
Hematocrit %
Folate, RBC 280-903 ng/mL
Test Performed By: ARUP Laboratories
500 Chipeta Way
Salt Lake City, UT 84108
Folate, Serum
Clinical Information: The term folate refers to all derivatives of folic acid. For practical purposes,
serum folate is almost entirely in the form of N-(5)-methyl tetrahydrofolate.(1) Approximately 20% of the
folate absorbed daily is derived from dietary sources; the remainder is synthesized by intestinal
microorganisms. Serum folate levels typically fall within a few days after dietary folate intake is reduced
and may be low in the presence of normal tissue stores. RBC folate levels are less subject to short-term
dietary changes. Significant folate deficiency is characteristically associated with macrocytosis and
megaloblastic anemia. Lower than normal serum folate also has been reported in patients with
neuropsychiatric disorders, in pregnant women whose fetuses have neural tube defects, and in women
who have recently had spontaneous abortions.(3) Folate deficiency is most commonly due to insufficient
dietary intake and is most frequently encountered in pregnant women or in alcoholics. Other causes of low
serum folate concentration include: -Excessive utilization (eg, liver disease, hemolytic disorders, and
malignancies) -Rare inborn errors of metabolism (eg, dihydrofolate reductase deficiency,
forminotransferase deficiency, 5,10-methylenetetrahydrofolate reductase deficiency, and tetrahydrofolate
methyltransferase deficiency)
Useful For: Investigation of suspected folate deficiency
Interpretation: Serum folate is a relatively nonspecific test.(3) Low serum folate levels may be seen in
the absence of deficiency and normal levels may be seen in patients with macrocytic anemia, dementia,
neuropsychiatric disorders, and pregnancy disorders. Results