Sorted By Test Name - Mayo Medical Laboratories

89067
FH1N1
91948
Equivocal: 20.1-24.9 U
Weakly positive: 25.0-34.9 U
Positive: > or =35.0 U
NEUTROPHIL-SPECIFIC ANTIBODIES
Negative (not detectable)
Clinical References: 1. Sandborn WJ, Loftus EV Jr, Homburger HA, et al: Evaluation of serological
disease markers in a population-based cohort of patients with ulcerative colitis and Crohn's disease.
Inflamm Bowel Dis 2001 Aug;7(3):192-201 2. Homburger HA, Unpublished Mayo information 3.
Vidrich A, Lee J, Janes E: Segregation of pANCA antigenic recognition by DNase treatment of
neutrophils: ulcerative colitis, type 1 autoimmune hepatitis, and primary sclerosing cholangitis. J Clin
Immunol 1995;Nov15(6):293-299
Inflammatory Myofibroblastic Tumors (IMT), 2p23
Rearrangement, FISH, Tissue
Clinical Information: Inflammatory myofibroblastic tumors (IMT) is a distinctive lesion composed
of myofibroblastic spindle cells accompanied by an inflammatory infiltrate of plasma cells, lymphocytes,
and eosinophils which occur primarily in the soft tissue and viscera of children and young adults. They
may arise in any anatomical site including lung, soft tissues, retroperitoneum, and bladder. The genetic
mechanisms underlying IMT pathogenesis are only partially known, but cytogenetic analyses have
disclosed chromosomal rearrangements involving the ALK gene at 2p23. Recently, studies support that
identification of ALK gene rearrangement is useful to differentiate IMTs from other spindle cell
neoplasms of soft tissue and viscera.
Useful For: As an aid in the diagnosis of inflammatory myofibroblastic tumors in detecting a
neoplastic clone associated with the rearrangement of the ALK gene at 2p23
Interpretation: A neoplastic clone is detected when the percent of cells with an abnormality exceeds
the normal cutoff for the ALK probe. A positive result is consistent with a subset of inflammatory
myofibroblastic tumors (IMT). A negative result suggests no rearrangement of the ALK gene region at
2p23. However, this result does not exclude the diagnosis of IMT.
Reference Values:
An interpretive report will be provided.
Clinical References: 1. Sukov WR, Cheville JC, Carlson AW, et al: Utility of ALK-1 protein
expression and ALK rearrangements in distinguishing inflammatory myofibroblastic tumor from
malignant spindle cell lesions of the urinary bladder. Mod Pathol 2007;20(5):592-603 Epub 2007 Mar 30
2. Tsuzuki T, Magi-Galluzzi C, Epstein JI, et al: ALK-1 expression in inflammatory myofibroblastic
tumor of the urinary bladder. Am J Surg Pathol 2004;28:1609-1614 3. Li XQ, Hisaoka M, Shi DR, et al:
Expression of anaplastic lymphoma kinase in soft tissue tumors: an immunohistochemical and molecular
study of 249 cases. Hum Pathol 2004 Jun;35(6):711-721 4. Griffin CA, Hawkins AL, Dvorak C, et al:
Recurrent involvement of 2p23 in inflammatory myofibroblastic tumours. Cancer Res 1999;59:2776-2780
Influenza A H1N1 (2009) Real-Time RT-PCR
Reference Values:
Reference Range: Not Detected
Test Performed By: Focus Diagnostics, Inc.
5785 Corporate Avenue
Cypress, CA 90630-4750
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