07.01.2013 Views

Sorted By Test Name - Mayo Medical Laboratories

Sorted By Test Name - Mayo Medical Laboratories

Sorted By Test Name - Mayo Medical Laboratories

SHOW MORE
SHOW LESS

You also want an ePaper? Increase the reach of your titles

YUMPU automatically turns print PDFs into web optimized ePapers that Google loves.

FBBCK<br />

91664<br />

FBEAN<br />

91646<br />

ASPE/Luminex approach is enhanced, with a better lower limit of detection in the range of 5% to 8%<br />

mutant alleles, with very high specificity.<br />

Useful For: Evaluating patients with chronic myeloid leukemia and Philadelphia chromosome positive<br />

B-cell acute lymphoblastic leukemia receiving tyrosine kinase inhibitor (TKI), therapy, who are<br />

apparently failing treatment This is the preferred initial test to identify the presence of acquired BCR-ABL<br />

mutations associated with TKI-resistance.<br />

Interpretation: The presence of 1 or more point mutations in the translocated portion of the ABL<br />

region of the BCR-ABL fusion mRNA is considered a positive result, indicating TKI (eg, imatinib)<br />

resistance.<br />

Reference Values:<br />

An interpretive report will be provided.<br />

Clinical References: 1. Hughes T, Deininger M, Hochhaus A, et al: Monitoring CML patients<br />

responding to treatment with tyrosone kinase inhibitors: review and recommendations for harmonizing<br />

current methodology for detecting BCR-ABL transcripts and kinase domain mutations and for expressing<br />

results. Blood 2006;108:28-37 2. Jabbour E, Kantarjian H, Jones D, et al: Frequency and clinical<br />

significance of BCR-ABL mutations in patients with chronic myeloid leukemia treated with imatinib<br />

mesylate. Leukemia 2006;20:1767-1773 3. Oncology NPGi. Chronic myelogenous leukemia: National<br />

Comprehensive Cancer Network; 2008 Available from URL:<br />

nccn.org/professionals/physician_gls/PDF/cml.pdf 4. Baccarani M, Saglio G, Goldman J, et al: Evolving<br />

concepts in the management of chronic myeloid leukemia: recommendations from an expert panel on<br />

behalf of the European Leukemia Net. Blood 2006;108:1809-1820 5. Jones D, Kamel-Reid S, Bahler D,<br />

et al: Laboratory practice guidelines for detecting and reporting BCR-ABL drug resistance mutations in<br />

chronic myelogenous leukemia and acute lymphoblastic leukemia A Report of the Association for<br />

Molecular Pathology. J Mol Diagn 2009;11:4-11<br />

Bean Black IgE<br />

Interpretation: Conventional RAST Scoring Guide Class IgE (kU/L Comment 0 or = 17.5 Strong Positive<br />

Reference Values:<br />

Hooray! Your file is uploaded and ready to be published.

Saved successfully!

Ooh no, something went wrong!