Sorted By Test Name - Mayo Medical Laboratories

LCJC
88909
JO1
80179
Reference Values:
This test, when not accompanied by a pathology consultation request, will be answered as either positive
or negative.
If additional interpretation/analysis is needed, please request 5439 Surgical Pathology Consultation
along with this test.
Clinical References: 1. Aksamit AJ, Mourrain P, Sever JL, Major EO: Progressive multifocal
leukoencephalopathy: investigation of three cases using in situ hybridization with JC virus biotinylated
DNA probe. Ann Neurol 1985;18:490-496 2. Telenti A, Aksamit AJ Jr, Proper J, Smith TF: Detection of
JC virus DNA by polymerase chain reaction in patients with progressive multifocal leukoencephalopathy.
J Infect Dis 1990;162:858-861 3. Aksamit AJ Jr: Nonradioactive in situ hybridization in progressive
multifocal leukoencephalopathy. Mayo Clin Proc 1993;68:899-910
JC Virus, Molecular Detection, PCR, Spinal Fluid
Clinical Information: JC virus (JCV), a member of the genus Polyomavirus, is a small nonenveloped
DNA-containing virus. Primary infection occurs in early childhood, with a prevalence of >80%.(1) The
virus is latent but can reactivate in immunosuppressed patients, especially those with AIDS. JCV is
recognized as the etiologic agent of progressive multifocal leukoencephalopathy (PML), a fatal
demyelinating disease of the central nervous system.(2,3) Histologic examination of brain biopsy tissue
may reveal characteristic pathologic changes localized mainly in oligodendrocytes and astrocytes.
Detection of JCV DNA by PCR (target gene, large T antigen) in the cerebrospinal fluid specimens of
patients with suspected PML infection has replaced the need for biopsy tissue for laboratory diagnosis.(4)
Importantly, the PCR test is specific with no cross-reaction with BK virus (BKV), a closely related
polyomavirus.
Useful For: As an aid in diagnosing progressive multifocal leukoencephalopathy due to JC virus
Interpretation: Detection of JC virus (JCV) DNA supports the clinical diagnosis of progressive
multifocal leukoencephalopathy due to JCV
Reference Values:
Not applicable
Clinical References: 1. Safak M, Khalili K: An overview: human polyomavirus JC virus and its
associated disorders. J Neurovirol 2006;9 Suppl 1:3-9 2. Khalili K, White MK: Human demyelinating
disease and the polyomavirus JCV. Mult Scler 2006 Apr;12(2):133-142 3. Ahsan N, Shah KV:
Polyomaviruses and human diseases. Adv Exp Med Biol 2006;577:1-18 4. Romero JR, Kimberlin DW:
Molecular diagnosis of viral infections of the central nervous system. Clin Lab Med 2003
Dec;23(4):843-865 5. Chen Y, Bord E, Tompkins T, et al: Asymptomatic reactivation of JC virus in
patients treated with natalizumab. N Engl J Med Sep 10 2009;361(11):1067-1074 6. Egli A, Infanti L,
Dumoulin A, et al: Prevalence of polyomavirus BK and JC infection and replication in 400 healthy
donors. J Infect Dis Mar 15 2009;199(6):837-846
Jo 1 Antibodies, IgG, Serum
Clinical Information: Jo 1 (histidyl tRNA synthetase) is a member of the amino acyl-tRNA
synthetase family of enzymes found in all nucleated cells. Jo 1 antibodies in patients with polymyositis
bind to conformational epitopes of the enzyme protein and inhibit its catalytic activity in vitro.(1) Jo 1
antibodies are a marker for the disease polymyositis, and occur most commonly in myositis patients who
also have interstitial lung disease. The antibodies occur in up to 50% of patients with interstitial
pulmonary fibrosis and symmetrical polyarthritis.(2) See Connective Tissue Disease Cascade (CTDC) in
Special Instructions and Optimized Laboratory Testing for Connective Tissue Diseases in Primary Care:
The Mayo Connective Tissue Diseases Cascade in Publications.
Useful For: Evaluating patients with signs and symptoms compatible with a connective tissue disease,
especially those patients with muscle pain and limb weakness, concomitant pulmonary signs and
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