Sorted By Test Name - Mayo Medical Laboratories

SAAS
89882
SAAI
89883
questioned. This is especially true for paraffin-embedded material: labeling accuracy may be questioned
or tissue from other sources may be included by mistake. Confirmation of the patient origin may be
critical to the clinical work-up of that patient. Molecular methods are now available to extract DNA from
various sources, including paraffin-embedded material, and to compare the molecular fingerprint
(genotype) of one specimen source with another one. Matching genotypes on multiple specimens suggest
that they are derived from the same patient, whereas differences in genotype suggest different patient
sources.
Useful For: Determining specimen origin when the patient identity of a specimen is in question
Interpretation: An interpretive report will be provided.
Clinical References: Sano K, Takayanagi K, Kaneko T, et al: Application of short tandem repeat of
genomic DNA and mitochondrial DNA for identification of mixed-up tissue specimens. Pathol Int
2000;50:1-6
Sperm Antibody, Direct, Semen
Clinical Information: Sperm antibodies are associated with some cases of infertility. For fertilization
to occur, the sperm head must first attach to the zona pellucida of the egg. Sperm antibodies interfere with
this binding. While there is consensus that these antibodies play a role in infertility, the percentage of
sperm that must be bound by antibodies before fertility is adversely affected is less clear.
Useful For: As the preferred test and specimen type (semen) for males suspected of sperm antibodies,
this test is indicated in the investigation of male infertility: -As a follow-up test when sperm agglutination
is noted in the ejaculate -In men with a history of testicular trauma, biopsy, vasectomy reversal, genital
tract infection, or obstructive lesions of the reproductive ductal system
Interpretation: Results are reported as: -Percentage of sperm with positive binding -Class of antibody
involved (IgG and IgA) -Site of binding (head, midpiece, tail, and/or tail tip) Greater than 50% binding is
usually required to significantly lower a patient's fertility. The significance of the percentage binding is
inversely related to the patientâ€s sperm count.
Reference Values: