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LPC<br />

83399<br />

LDSBS<br />

89406<br />

(LSD) to 2-oxo-3-hydroxy LSD (O-H-LSD) in human liver microsomes and cryopreserved human<br />

hepatocytes. J Anal Toxicol 2000;24:550-556<br />

Lysophosphatidylcholine, Plasma<br />

Clinical Information: Plasma lysophosphatidylcholine (LPC) concentration is diminished in patients<br />

with lecithin cholesterol acyltransferase (LCAT) deficiency. LCAT is the enzyme responsible for<br />

synthesizing the majority of cholesteryl esters in serum by transferring fatty acid from<br />

phosphatidylcholine to the 3-hydroxyl group of cholesterol. It is believed that LCAT regulates the<br />

transport of cholesterol between extravascular and intravascular pools. In the theoretical pathway known<br />

as reverse cholesterol transport, cholesterol is moved from peripheral tissues to the liver for catabolism.<br />

The esterification of cholesterol by LCAT in serum serves to maintain a chemical concentration gradient<br />

for unesterified cholesterol between peripheral tissue cells and the serum. LPC additionally has been<br />

shown to play a functional role in various biological processes including cell migration, cell proliferation,<br />

angiogenesis, and inflammation. LPC stimulates monocyte chemoattractant protein-1 and induces<br />

expression of adhesion molecules on the surface of endothelial cells and, thus, may play a role in coronary<br />

atherogenesis.<br />

Useful For: Detecting lecithin cholesterol acyltransferase deficiency<br />

Interpretation: Decreased values for 16:0 lysophosphatidylcholine (LPC) and 18:0 LPC are consistent<br />

with lecithin cholesterol acyltransferase deficiency.<br />

Reference Values:<br />

16:0 LYSOPHOSPHATIDYLCHOLINE<br />

> or =16 years: > or =62 mcmol/L<br />

18:0 LYSOPHOSPHATIDYLCHOLINE<br />

> or =16 years: > or =20 mcmol/L<br />

Reference values have not been established for patients that are

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