Sorted By Test Name - Mayo Medical Laboratories

SULFU
81815
9851
FSULF
90072
1983;15:107-113 4. Goodman, Gilman's: The Pharmacological Basis of Therapeutics. 11th edition.
McGraw-Hill Publishing, 2006, p 1112
Sulfate, Urine
Clinical Information: Urinary sulfate is a reflection of dietary protein intake, particularly meat, fish,
and poultry, which are rich in sulfur-containing amino acids methionine and cysteine. Urinary sulfate can
be used to assess dietary protein intake for nutritional purposes. A protein-rich diet has been associated
with an increased risk for stone formation, possibly due, in part, to an increase in urinary calcium
excretion caused by acid production from metabolism of sulfur-containing amino acids.(2,3) Indeed,
urinary sulfate excretion is higher in patients who have kidney stones than in individuals who do not form
stones. Thus, urinary sulfate excretion may provide an index for protein-induced calciuria.(2) Sulfate is a
major anion in the urine that has significant affinity for cations and modulates the availability of cations
for reacting with other anions in the urine. It thus is an important factor of urinary supersaturation(4) for
various crystals or stones such as calcium oxalate, hydroxyapatite, and brushite. For example, a high
sulfate concentration may modulate the availability of calcium for reacting with oxalate and thus affect
the propensity for calcium oxalate stone or crystal formation. Urinary sulfate also has a major impact on
buffering or providing hydrogen ions and as such modulates the supersaturation of uric acid.
Useful For: Urinary sulfate can be used to assess the nutrition intake of animal protein. It also can be a
reflection of protein intake and can be assessed in patients with stone disease as related to stone
supersaturation and prevention of stone disease.
Interpretation: Urinary sulfate is a reflection of dietary protein intake, particularly of meat, and thus
can be used as an index of nutritional protein intake. It also is used in the calculation of urinary
supersaturation of various crystals or stones.
Reference Values:
7-47 mmol/specimen
Clinical References: 1. Houterman S, van Faassen A, Ocke MC, et al: Is urinary sulfate a biomarker
for the intake of animal protein and meat? Cancer Lett 1997;114:295-296 2. Tschope W, Ritz E:
Sulfur-containing amino acids are a major determinant of urinary calcium. Miner Electrolyte Metab
1985;11:137-139 3. Puche RC, Vacarro D, Sanchez A, et al: Increased fractional excretion of sulphate in
stone formers. Br J Urol 1993;71:523-526 4. Parks JH, Coward M, Coe FL: Correspondence between
stone composition and urine supersaturation in nephrolithiasis. Kidney Int 1997;51:894-900
Sulfated Alcian Blue (SAB) Stain
Useful For: Histologic staining method for amyloid, collagen, mast cells, and mucopolysaccharides.
Reference Values:
The laboratory will provide a pathology consultation and stained slide.
Sulfatide Autoantibody Test
Reference Values:
Interpretive Criteria
Interpretation and Comments provided on each report.
Interpretation and Comments vary. They are dependent upon
results.
Reference Range:
Immunoglobin Mild/Moderate
Isotype Normal Elevated Highly Elevated
IgM < 1500 > or = 1500 Not applicable
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