DƯỢC LÍ Goodman & Gilman's The Pharmacological Basis of Therapeutics 12th, 2010

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SECTION I
GENERAL PRINCIPLES
Table 4–11
Some Common Antidotes and Their Indications
ANTIDOTE
Acetylcysteine
Atropine sulfate
Benztropine
Bicarbonate, sodium
Bromocriptine
Calcium gluconate
or chloride
Carnitine
Crotalidae polyvalent
immune Fab
Dantrolene
Deferoxamine
Digoxin immune Fab
Diphenhydramine
Dimercaprol (BAL)
EDTA, CaNa 2
Ethanol
Fomepizole
Flumazenil
Glucagon hydrochloride
Hydroxocobalamin
hydrochloride
Insulin (high dose)
Leucovorin calcium
Methylene blue
Naloxone hydrochloride
Octreotide acetate
Oxygen, hyperbaric
Penicillamine
Physostigmine salicylate
Pralidoxime chloride
(2-PAM)
Pyridoxine
hydrochloride
Succimer (DMSA)
Thiosulfate, sodium
Vitamin K 1
(phytonadione)
POISONING INDICATION(S)
Acetaminophen
Organophosporus and
carbamate pesticides
Drug-induced dystonia
Na + channel blocking drugs
Neuroleptic malignant syndrome
Ca 2+ channel blocking drugs,
Fluoride
Valproate hyperammonemia
North American crotaline
snake envenomation
Malignant hyperthermia
Iron
Cardiac glycosides
Drug-induced dystonia
Lead, mercury, arsenic
Lead
Methanol, ethylene glycol
Methanol, ethylene glycol
Benzodiazepines
β adrenergic antagonists
Cyanide
Ca 2+ channel blockers
Methotrexate
Methemoglobinemia
Opioids
Sulfonylurea-induced
hypoglycemia
Carbon monoxide
Lead, mercury, copper
Anticholinergic syndrome
Organophosphorus pesticides
Isoniazid seizures
Lead, mercury, arsenic
Cyanide
Coumarin, indanedione
discussion of household, industrial, or environmental
chemicals, and they may lack detailed discourse of
prevention, identification, and treatment of overdose.
Additional information on poisoning from drugs and
chemicals can be found in many dedicated books of
toxicology (Flomenbaum, 2006; Klaassen, 2007; Olson,
2007; Shannon et al., 2007). A popular computer database
for information on toxic substances is POISINDEX
(Micromedex, Inc., Denver, CO).
The National Library of Medicine offers informa -
tion on toxicology and environmental health (http://sis.
nlm.nih.gov/enviro.html), including a link to ToxNet
(http://toxnet.nlm.nih.gov/), a cluster of full-text and
bibliographic databases on toxicology, hazardous chem -
icals, and related areas.
Regional poison control centers are a resource for
valuable poisoning information, and can be reached
from anywhere within the U.S. through a national
PoisonHelp hotline: 1-800-222-1222. Poison centers
also collect epidemiological data regarding poisoning,
perform all hazards surveillance, provide education,
and work collaboratively with other agencies to effect
poisoning prevention.
BIBLIOGRAPHY
American Academy of Clinical Toxicology, and the European
Association of Poisons Centres and Clinical Toxicologists.
Position statement and practice guidelines on the use of multidose
activated charcoal in the treatment of acute poisoning.
Clin Toxicol, 1999, 37:731–751.
American Academy of Clinical Toxicology, and the European
Association of Poisons Centres and Clinical Toxicologists.
Position paper: Gastric lavage. J Toxicol Clin Toxicol, 2004,
42:933–943.
American Academy of Clinical Toxicology, and the European
Association of Poisons Centres and Clinical Toxicologists.
Position paper: Single-dose activated charcoal. Clin Toxicol,
2005, 43:61–87.
American Academy of Pediatrics Committee on Injury, Violence,
and Poison Prevention. Poison treatment in the home.
Pediatrics, 2003, 112:1182–1185.
Arizona Center for Education and Research on Therapeutics.
Drugs that prolong the QT interal and/or induce torsades de
pointes ventricular arrhythmia. http://www.azcert.org/medicalpros/drug-lists/drug-lists.cfm.
Accessed January 23, 2010.
Barbui C, Esposito E, Cipriai A. Selective serotonin reuptake
inhibitors and risk of suicide: A systematic review of
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Bates DW, Boyle DL, Vander Bliet MB, et al. Relationship
between medication errors and adverse drug events. J Gen
Intern Med, 1995, 10:199–205.
Bronstein AC, Spyker DA, Cantilena LR, et al. 2007 Annual
Report of the American Association of Poison Control Centers’
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Clin Toxicol, 2008, 46:927–1057.
Buckley NA, Whyte IM, O’Connell DL, Dawson AH.
Activated charcoal reduces the need for N-acetylcysteine
treatment after acetaminophen overdose. Clin Toxicol, 1999,
37:753–757.
Dart RC, Erdman AR, Olson KR, et al. Acetaminophen
poisoning: an evidence-based consensus guideline for out-ofhospital
management. Clin Toxicol, 2006, 44:1–18.