22.05.2022 Views

DƯỢC LÍ Goodman & Gilman's The Pharmacological Basis of Therapeutics 12th, 2010

Create successful ePaper yourself

Turn your PDF publications into a flip-book with our unique Google optimized e-Paper software.

Leggas M, Adachi M, Scheffer GL, et al. MRP4 confers

resistance to topotecan and protects the brain from

chemotherapy. Mol Cell Biol, 2004, 24:7612–7621.

Lesch KP, Bengel D, Heils A, et al. Association of anxietyrelated

traits with a polymorphism in the serotonin transporter

gene regulatory region. Science, 1996, 274:1527–1531.

Leslie E, Deeley R, Cole S. Multidrug resistance proteins:

role of P-glycoprotein, MRP1, MRP2 and BCRP (ABCG2)

in tissue defense. Toxicol Appl Pharmacol, 2005, 204:216–

237.

Li C, Krishnamurthy PC, Penmatsa H, et al. Spatiotemporal

coupling of cAMP transporter to CFTR chloride channel

function in the gut epithelia. Cell, 2007, 131:940–951.

Lin JH, Yamazaki M. Clinical relevance of P-glycoprotein in

drug therapy. Drug Metab Rev, 2003, 35:417–454.

Locher KP, Lee AT, Rees DC. The E.coli BtuCD structure: A

framework for ABC transporter architecture and mechanism.

Science, 2002, 296:1091–1098.

Matsushima S, Maeda K, Ishiguro N, et al. Investigation of the

inhibitory effects of various drugs on the hepatic uptake of

fexofenadine in humans. Drug Metab Dispos, 2008, 36:663–

669.

Matsushima S, Maeda K, Kondo C, et al. Identification of the

hepatic efflux transporters of organic anions using doubletransfected

Madin-Darby canine kidney II cells expressing

human organic anion-transporting polypeptide 1B1 (OATP1B1)/

multidrug resistance-associated protein 2, OATP1B1/multidrug

resistance 1, and OATP1B1/breast cancer resistance protein.

J Pharmacol Exp Ther, 2005, 314:1059–1067.

Mizuno N, Niwa T, Yotsumoto Y, Sugiyama Y. Impact of drug

transporter studies on drug discovery and development.

Pharmacol Rev, 2003, 55:425–461.

Mori S, Takanaga H, Ohtsuki S, et al. Rat organic anion

transporter 3 (rOAT3) is responsible for brain-to-blood efflux

of homovanillic acid at the abluminal membrane of brain

capillary endothelial cells. J Cereb Blood Flow Metab, 2003,

23:432–440.

Murphy DL, Lerner A, Rudnick G, Lesch KP. Serotonin

transporter: Gene, genetic disorders, and pharmacogenetics.

Mol Interven, 2004, 4:109–123.

Mwinyi J, Johne A, Bauer S, et al. Evidence for inverse effects

of OATP-C (SLC21A6) 5 and 1b haplotypes on pravastatin

kinetics. Clin Pharmacol Ther, 2004, 75:415–421.

Naesens M, Kuypers DRJ, Verbeke K, Vanrenterghem Y.

Multidrug resistance protein 2 genetic polymorphisms

influence mycophenolic acid exposure in renal allograft

recipients. Transplantation, 2006, 82:1074–1084.

Nezu J, Tamai I, Oku A, et al. Primary systemic carnitine

deficiency is caused by mutations in a gene encoding sodium

ion–dependent carnitine transporter. Nature Genet, 1999,

21:91–94.

Niemi M, Backman JT, Kajosaari LI, et al. Polymorphic organic

anion transporting polypeptide 1B1 is a major determinant of

repaglinide pharmacokinetics. Clin Pharmacol Ther, 2005,

77:468–478.

Niemi M, Schaeffeler E, Lang T, et al. High plasma pravastatin

concentrations are associated with single nucleotide

polymorphisms and haplotypes of organic anion transporting

polypeptide-C (OATP-C, SLCO1B1). Pharmacogenetics,

2004, 14:429–440.

Ocheltree SM, Shen H, Hu Y, et al. Mechanisms of cefadroxil

uptake in the choroid plexus: Studies in wild-type and PEPT2

knockout mice. J Pharmacol Exp Ther, 2004, 308:462–467.

Okuda M, Saito H, Urakami Y, et al. cDNA cloning and

functional expression of a novel rat kidney organic cation

transporter, OCT2. Biochem Biophys Res Commun, 1996,

224:500–507.

Olivier B, Soudijn W, van Wijngaarden I. Serotonin, dopamine

and norepinephrine transporters in the central nervous system

and their inhibitors. Prog Drug Res, 2000, 54:59–119.

Oostendorp RL, Buckle T, Beijnen JH, et al. The effect of P-gp,

BCRP and P-gp/BCRP inhibitors on the in vivo absorption,

distribution, metabolism and excretion of imatinib. Invest New

Drugs, 2008, 27:31–40.

Osato DH, Huang CC, Kawamoto M, et al. Functional

characterization in yeast of genetic variants in the human

equilibrative nucleo-side transporter, ENT1. Pharmacogenetics,

2003, 13:297–301.

Ose A, Ito M, Kusuhara H, et al. Limited brain distribution of

[3R,4R,5S]-4-acetamido-5-amino-3-(1-ethylpropoxy)-1-

cyclohexene-1-carboxylate phosphate (Ro 64-0802), a

pharmacologically active form of oseltamivir, by active efflux

across the blood-brain barrier mediated by organic anion

transporter 3 (OAT3/SLC22A8) and multidrug resistanceassociated

protein 4 (MRP4/ABCC4). Drug Metab Dispos,

2009, 37:315–321.

Otsuka M, Matsumoto T, Morimoto R, et al. A human transporter

protein that mediates the final excretion step for toxic organic

cations. Proc Natl Acad Sci USA, 2005, 102:17923–17928.

Pascual JM, Wang D, Lecumberri B, et al. GLUT1 deficiency

and other glucose transporter diseases. Eur J Endocrinol,

2004, 150:627–633.

Paulusma CC, Bosma PJ, Zaman GJ, et al. Congenital jaundice

in rats with a mutation in a multidrug resistance-associated

protein gene. Science, 1996, 271:1126–1128.

Pinkett HW, Lee AT, Lum P, et al. An inward-facing

conformation of a putative metal-chelate-type ABC

transporter. Science, 2006, 315:373–377.

Polli JW, Olson KL, Chism JP, et al. An unexpected synergist

role of P-glycoprotein and breast cancer resistance protein on

the CNS penetration of the tyrosine kinase inhibitor lapatinib

(GW572016). Drug Metab Dispos, 2009, 37:439–442.

Rader, D.J. Regulation of reverse cholesterol transport and

clinical implications. Am J Cardiol, 2003, 92:42J–49J.

Rader DJ. Molecular regulation of HDL metabolism and

function: Implications for novel therapies. J Clin Invest, 2006,

116:3090–3100.

Reuss L. Basic mechanisms of ion transport. In, The Kidney:

Physiology and Pathophysiology (Seldin D, Giebisch G,

eds.), Lippincott Williams & Wilkins, Baltimore, 2000, pp.

85–106.

Sadee W, Drubbisch V, Amidon GL. Biology of membrane

transport proteins. Pharm Res, 1995, 12:1823–1837.

Sadeque AJ, Wandel C, He H. Increased drug delivery to the

brain by P-glycoprotein inhibition. Clin Pharmacol Ther,

2000, 68:231–237.

Sasaki M, Suzuki H, Ito K. Transcellular transport of organic

anions across a double-transfected Madin-Darby canine

kidney II cell monolayer expressing both human organic

anion-transporting polypeptide (OATP2/SLC21A6) and

119

CHAPTER 5

MEMBRANE TRANSPORTERS AND DRUG RESPONSE

Hooray! Your file is uploaded and ready to be published.

Saved successfully!

Ooh no, something went wrong!