DƯỢC LÍ Goodman & Gilman's The Pharmacological Basis of Therapeutics 12th, 2010

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Table 19–2
Pharmacological Properties of Parenteral Anesthetics
SECTION II
NEUROPHARMACOLOGY
IV INDUCTION MINIMAL HYPNOTIC INDUCTION DOSE t 1/2
β CL (mL· PROTEIN V SS
DRUG FORMULATION DOSE (mg/kg) LEVEL (μg/mL) DURATION (min) (HOURS) min –1·kg–1 ) BINDING (%) (L/kg)
Thiopental 25 mg/mL in aqueous 3-5 15.6 5-8 12.1 3.4 85 2.3
solution + 1.5 mg/
mL Na 2
CO 3
;
pH = 10–11
Methohexital 10 mg/mL in aqueous 1-2 10 4-7 3.9 10.9 85 2.2
solution + 1.5 mg/
mL Na 2
CO 3
;
pH = 10–11
Propofol 10 mg/mL in 10% 1.5-2.5 1.1 4-8 1.8 30 98 2.3
soybean oil,
2.25% glycerol,
1.2% egg PL,
0.005% EDTA or
0.025% Na-MBS;
pH = 4.5–7
Etomidate 2 mg/mL in 35% PG; 0.2-0.4 0.3 4-8 2.9 17.9 76 2.5
pH = 6.9
Ketamine 10, 50, or 100 mg/mL 0.5-1.5 1 10-15 3.0 19.1 27 3.1
in aqueous solution;
pH = 3.5–5.5
t 1/2
β, β phase half-life; CL, clearance; V ss
, volume of distribution at steady state; EDTA, ethylenediaminetetraacetic acid; Na-MBS, Na-metabisulfite; PG, propylene glycol;
PL, phospholipid.