DƯỢC LÍ Goodman & Gilman's The Pharmacological Basis of Therapeutics 12th, 2010

Quinine sulfate P. falciparum from 542 mg base 8.3 mg base/kg (10 mg Cinchonism e , sinus Combine with tetracycline,
(oral) chloroquine- (650 mg salt) d salt/kg) orally 3 times arrhythmia, doxycycline, or clindamycin, except
resistant areas orally 3 times daily × 3 d (infections junctional rhythms, for P. vivax infections in children
P. vivax from daily × 3 d acquired outside atrioventricular <8 y or pregnant women
chloroquine- (infections acquired Southeast Asia) to 7 d block, prolonged QT Contraindicated in hypersensitivity
resistant areas outside Southeast (infections acquired in interval, ventricular including history of blackwater
Asia) to 7 d SE Asia) tachycardia, ventricular fever, thrombocytopenic purpura,
(infections acquired fibrillation (these or thrombocytopenia associated
in SE Asia) are rare and more with quinine or quinidine use; many
commonly seen cardiac conduction defects and
with quinidine), arrhythmias f ; myasthenia gravis;
hypoglycemia
optic neuritis
Quinidine Severe malaria 6.25 mg base/kg Same as adult Cinchonism, Combine with tetracycline,
gluconate (all species, (= 10 mg salt/kg) tachycardia, doxycycline, or clindamycin
(IV) independently loading dose IV over prolongation of Contraindicated in hypersensitivity;
of chloroquine 1-2 h, then 0.0125 mg QRS and QTc histo ry of blackwater fever
resistance) base/kg/min intervals, flattening including history of blackwater
Patient unable (0.02 mg salt/kg/min) of T-wave (effects fever, thrombocytopenic purpura or
to take oral continuous infusion are often transient) thrombocytopenia associated with
medication for at least 24 h Ventricular quinine or quinidine use; many
Parasitemia >10% Alternative regimen: g arrhythmias, cardiac conduction defects and
hypotension,
arrhythmias h ; myasthenia gravis;
hypoglycemia
optic neuritis
CHAPTER 49
CHEMOTHERAPY OF MALARIA
(Continued)
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