DƯỢC LÍ Goodman & Gilman's The Pharmacological Basis of Therapeutics 12th, 2010

100
Extracellular
SECTION I
GENERAL PRINCIPLES
Intracellular
Figure 5–6. Predicted secondary structure of MRP2 based on hydropathy analysis. The dark blue circles depict glycosylation sites;
Walker A motif is colored light blue; black boxes represent the Walker B motif. Light gray is the middle region between the two
motifs. The Walker A motifs interact with α and β phosphates of di- and tri-nucleotides; the Walker B motifs help to coordinate Mg 2 .
http://www.bioparadigms.org/slc/intro.asp (SLC super family),
http://www.pharmaconference.org/slctable.asp (SLC
superfamily), and http://www.TP_Search.jp/ (drug transporters).
Information on pharmacogenetics of these
transporters can be found in Chapter 7 and at http://
www.pharmgkb.org and http://www.pharmacogenetics.
ucsf.edu.
SLC Transporters. The solute carrier (SLC) superfamily
includes 48 families and represents ~315 genes in the
human genome. The nomenclature of the transporters
within each family is listed at http://www.genenames.org/
aboutHGNC.html. Table 5–2 lists the families in the
human SLC superfamily and some of the genetic diseases
that are associated with members of selected
S. aureus Sav1866
Multidrug exporter
A. fulgidus ModBC-A
MoO 4 /WO 4 importer
E. coli Btu-CD
Vitamin B 12 importer
H. influenzae HI1470/1
Metal-chelate importer
Figure 5–7. Structure of four crystallized ABC transporters from microorganisms. The structures show the intracellular nucleotide
binding domains (NBDs) along with the transmembrane alpha helices. Structure was reconstructed by Libusha Kelly using the coordinates
deposited in the Protein Data Bank (PDB; http://www.rcsb.org/pdb/).