DƯỢC LÍ Goodman & Gilman's The Pharmacological Basis of Therapeutics 12th, 2010

Table 8–1
Responses of Effector Organs to Autonomic Nerve Impulses (Continued)
ADRENERGIC
CHOLINERGIC
RECEPTOR PARASYMPATHETIC RECEPTOR
ORGAN SYSTEM SYMPATHETIC EFFECT a SUBTYPE b EFFECT a SUBTYPE b
Intestine
Motility and tone Decrease h + α 1
, α 2
, β 1
, β 2
a i +++ M 3
, M 2
Sphincters Contraction+ α 1
Relaxation (usually)+ M 3
, M 2
Secretion b α 2
a++ M 3
, M 2
Gallbladder and Ducts Relaxation+ β 2
Contraction+ M
Kidney
Renin secretion b+; a++ α 1
; β 1
No innervation —
Urinary Bladder
Detrusor Relaxation+ β 2
Contraction+++ M 3
> M 2
Trigone and sphincter Contraction++ α 1
Relaxation++ M 3
> M 2
Ureter
Motility and tone a α 1
a (?) M
Uterus Pregnant contraction; α 1
Relaxation β 2
Variable j M
Nonpregnant relaxation β 2
Sex Organs, Male Ejaculation+++ α 1
Erection+++ M 3
Skin
Pilomotor muscles Contraction++ α 1
—
Sweat glands Localized secretion k ++ α 1
—
— Generalized secretion+++ M 3
, M 2
Spleen Capsule Contraction+++ α 1
— —
Relaxation+ β 2
—
Adrenal Medulla — Secretion of epinephrine N (α 3
) 2
(β 4
) 3
; M
and norepinephrine (secondarily)
Skeletal Muscle Increased contractility; β 2
— —
glycogenolysis; K + uptake
Liver Glycogenolysis and α 1
— —
gluconeogenesis+++ β 2
Pancreas
Acini b secretion+ α Secretion++ M 3
, M 2
Islets (β cells) b secretion+++ α 2
—
a secretion+ β 2
Fat Cells l Lipolysis+++; thermogenesis α 1
, β 1,
β 2,
β 3
— —
Inhibition of lipolysis α 2
Salivary Glands K + and water secretion+ α 1
K + and water secretion+++ M 3
, M 2
Nasopharyngeal — Secretion++ M 3
, M 2
Glands
Pineal Glands Melatonin synthesis β —
Posterior Pituitary ADH secretion β 1
—
(Continued)