DƯỢC LÍ Goodman & Gilman's The Pharmacological Basis of Therapeutics 12th, 2010

2010
INDEX
Celecoxib (Cont.):
COX isoform selectivity, 962f
distribution of, 991
dosage and administration of, 970t
elimination, 991
pharmacokinetics of, 970t, 991,
1822t
pharmacology of, 962f
plama binding of, 1822t
plasma pharmacokinetics of, 962f
structure of, 991
therapeutic uses of, 970t, 991
Celiac ganglion, 173f
Celiprolol, 312f, 329–330
Cell-based screening, in drug
development, 4
CELLCEPT (mycophenolate mofetil),
1822–1823
Cell cycle, in neoplastic disease,
1671–1673
Cell membranes
carrier-mediated transport across, 19
characteristics of, 17
composition of, 17
electrolytes and transport across,
18–19
facilitated diffusion across, 19
passive flux across, 18
permeability of, 17
pH and transport across, 18–19
in pharmacokinetics, 17–19, 18f
Cellular assays, 154
Cellulitis, 1817
orbital, 1780–1781
CENESTIN (conjugated estrogens), 1839t
Centrally acting adrenergic agents as,
antihypertensive agents, 774t
Central nervous system (CNS)
action of drugs in, 390–393
adrenocorticosteroids and, 1221
amino acids in, 376
amphetamines and, 298
angiotensin II and, 729
aspartate in, 379–380
barbiturates and, 469–472
benzodiazepines and, 460
beta-adrenergic receptor antagonists
and, 317
cannabinoids in, 388
carbon dioxide and, 562
cell signaling in, 373–376
depressants, 390–392, 654–657
distribution of drugs and, 25
dopamine and, 355–356
drug discovery, 393
Central nervous system (CNS) (Cont.):
drug interactions, 392–393
eicosanoids and, 951
epinephrine and, 285
ethanol and, 633–635
fentanyl and, 507
GABA in, 376–379
glutamate in, 379–380
glycine in, 379
histamine and, 384–388, 915
H 1
receptor antagonists and,
919–920
integrative chemical communication
in, 366–371
lipid mediators in, 389–390
meperidine and, 503–505
methadone and, 508
muscarinic antagonists and, 230,
233–234
neuromuscular blocking agents and,
261–262
neurotransmitter receptor-effector
coupling in, 371–372
nicotine and, 271
nitric oxide in, 390
organizational principles of,
363–366
plasticity of, 366
repair of, 366
serotonin and, 341–342
stimulants, 392
supportive cells in, 365
synaptic transmission in, 373–376
transmitter interactions, 393
vasopressin and, 708
Central nervous system depressants,
654–657
Central neurotransmitters, 376–390
Cephalexin
antibacterial spectrum of, 1496t
chemistry of, 1494t
dosage and dosage forms of, 1494t
pharmacokinetics of, 29, 1822t
Cephalosporins
antibacterial spectrum of, 1496t
bacterial resistance to, 1481–1483,
1493, 1496
chemistry of, 1494t
for deep cutaneous infections, 1817
dosage and dosage forms of, 1494t
drug interactions with, 1529
first-generation, 1494t, 1496t, 1497
fourth-generation, 1494t, 1496t,
1498–1499
general features of, 1496–1497
Cephalosporins (Cont.):
mechanism of action of, 1478–1481
second-generation, 1494t, 1496t,
1497
therapeutic uses of, 1499
third-generation, 1494t, 1496t,
1497–1498
Cephalothin
antibacterial spectrum of, 1496t
chemistry of, 1494t
dosage and dosage forms of, 1494t
CEPTA (ceftazidime), 1496t
Cerebellum, 364
alpha adrenergic receptors in, 203t
Cerebral cortex, 363–364
Cerebral edema, corticosteroids for,
1234
Cerebrospinal fluid (CSF)
distribution of drugs and, 25
penicillin distribution of, 1485
Cerebrospinal fluid (CSF) barrier
intrathecal injection and, 22
transporters and, 116
Cerebrovascular disease, 877
and dyslipidemia treatment, 890
risk assessment, 885–887
Cerivastatin, 896
drug interactions with, 110
Certolizumab, 994t
CERVAGEM (gemeprost), 1837
Cervical cancer, drugs for,
1668t–1670t
Cervical ganglia, 173f
Cervical ripening, 1849–1850
prostaglandin E 2
for, 952
Cervicitis, 1842t
CERVIDIL (dinoprostone), 1849
Cestode infections, 1447–1448
Cetirizine, 921t, 924, 1816
pharmacokinetics of, 1816t, 1823t
CETP. See Cholesteryl ester transfer
protein (CETP)
Cetrorelix, 1119t, 1843
structure of, 1764t
CETROTIDE (cetrorelix), 1119t, 1764t,
1843
Cetuximab, 1734, 1745, 1746t
absorption, 1736
adverse effects and side effects of,
1737
chemistry, 1736
distribution of, 1736
dosage and administration of, 1747t
elimination, 1736
mechanism of action of, 1736