DƯỢC LÍ Goodman & Gilman's The Pharmacological Basis of Therapeutics 12th, 2010

Table 53–2
Names, Structural Formulas, Dosage, and Dosage Forms of Selected Cephalosporins and Related Compounds
1
7
R 1
t 1
2
Cephem nucleus
R 2
COMPOUND
DOSAGE FORMS, a ADULT DOSAGE
(TRADE NAMES) R 1
R 2
FOR SEVERE INFECTION, AND
First generation
Cefadroxil
(DURICEF)
O: 1 g every 12 hours
= 1.1 hours
t 1
2
t 1
2
t 1
2
Cefazolin
(ANCEF, KEFZOL, others)
I: 1-1.5 g every 6 hours
= about 2 hours
t 1
2
Cephalexin
(KEFLEX, others)
O: 1 g every 6 hours
= 0.9 hour
t 1
2
Second generation
Cefaclor
(CECLOR)
O: 1 g every 8 hours
= 0.7 hours
Ceforanide
(PRECEF)
I: 1 g every 12 hours
= 2.6 hours
t 1
2
CH 2
t 1
2
Cefotetan
(CEFOTAN)
CH 2 NH 2
I: 2-3 g every 12 hours
= 3.3 hours
Cefoxitin b
(MEFOXIN)
I: 2 g every 4 hours or 3 g every 6 hours
= 0.7 hours
t 1
2
Cefprozil
(CEFZIL)
HO
O: 500 mg every 12 hours
CH CH CH 2 t 1 = 1.3 hours
2
NH 2
Cefuroxime acetil c
(CEFTIN)
Cefuroxime
(ZINACEF)
I: up to 3 g every 8 hours
= 1.7 hours
t 1
2
T: 500 mg every 12 hours
(Continued)