DƯỢC LÍ Goodman & Gilman's The Pharmacological Basis of Therapeutics 12th, 2010

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SECTION II
NEUROPHARMACOLOGY
Table 15–1
Antidepressants: Chemical Structures, Dose and Dosage Forms, and Side Effects
AMINE
NONPROPRIETARY NAME (TRADE NAME) DOSE AND DOSAGE FORMS EFFECTS SIDE EFFECTS
Norepinephrine Reuptake Inhibitors:
Tertiary Amine Tricyclics
R 1
Usual a
Anti-
Dose Dosage Hypo- cholinergic GI Weight Sexual Cardiac
R 3 R 2
(mg/day) Form Agitation Seizures Sedation tension Effects Effects Gain Effects Effects
R 1 R 2 R 3
Amitriptyline (ELAVIL and others) 100–200 O, I NE, 5-HT 0 2+ 3+ 3+ 3+ 0/+ 2+ 2+ 3+
C H C Ó CH(CH 2
) 2
N(CH 3
) 2
Clomipramine (ANAFRANIL) 100–200 O NE, 5-HT 0 3+ 2+ 2+ 3+ + 2+ 3+ 3+
C CI N—(CH 2
) 3
N(CH 3
) 2
Doxepin (ADAPIN, SINEQUAN) 100–200 O NE, 5-HT 0 2+ 3+ 2+ 2+ 0-+ 2+ 2+ 3+
O H C Ó CH(CH 2
) 2
N(CH 3
) 2
Imipramine (TOFRANIL and others) 100–200 O, I NE, 5-HT 0/+ 2+ 2+ 2+ 2+ 0/+ 2+ 2+ 3+
C H N—(CH 2
) 3
N(CH 3
) 2
(+)-Trimipramine (SURMONTIL) 75–200 O NE, 5-HT 0 2+ 3+ 2+ 3+ 0/+ 2+ 2+ 3+
C H
Norepinephrine Reuptake Inhibitors:
Secondary Amine Tricyclics
Amoxapine (ASENDIN) 200–300 O NE, DA 0 2+ + 2+ + 0/+ + 2+ 2+
Desipramine (NORPRAMIN) 100–200 O NE + + 0/+ + + 0/+ + 2+ 2+