DƯỢC LÍ Goodman & Gilman's The Pharmacological Basis of Therapeutics 12th, 2010

Nitrogen mustards, 1668t–1670t,
1682–1684
Nitroglycerin
absorption, fate, and excretion of,
757
adverse effects and side effects of,
755
cardiovascular effects, with longterm
use, 752
chemistry of, 753
cutaneous administration, 760
dosage and administration of, 754t
history of, 753
intravenous, therapeutic uses of, for
heart failure, 796
oral, 759–760
pharmacokinetics of, 1869t
preparations, 754t
for prevention of preterm labor,
1848
structure of, 754t
sublingual administration of, 759
therapeutic uses of
in myocardial infarction, 760–761
for unstable angina, 760
transmucosal or buccal
administration, 760
NITROL (nitroglycerin), 754t
NITROPRESS (sodium nitroprusside),
795–796
Nitroprusside, 793
Nitrosoureas, 1668t–1670t, 1686
NITROSTAT (nitroglycerin), 754t
Nitrous oxide
clinical uses of, 551
pharmacokinetics of, 551
side effects of, 551–552
cardiovascular, 551
gastrointestinal, 552
hepatic, 552
muscular, 552
neurological, 551–552
renal, 552
respiratory, 551
Nitrovasodilators, 753
as antianginal agents, 752
for congestive heart failure, 793–795
Nizatidine
pharmacokinetics of, 1816t
therapeutic uses of, for ulcers, 1319t
NIZORAL (ketoconazole), 1841
NMR. See Nuclear magnetic resonance
(NMR) spectroscopy
NNMT. See Nicotinamide N-
methyltransferase (NNMT)
NO. See Nitric oxide (NO)
Nobel, Alfred, 753
Nocardiosis, sulfonamides for, 1467
Nocturnal acid breakthrough, 1318
Nodal depolarizations, premature,
management of, 824t
NOLAHIST (phenindamine tartrate), 921t
Nolvadex Adjuvant Trial Organization
(NATO), 1758
Nomenclature, of genomic regions,
148f
Nomifensine, potencies at human
transporters for monamine
neurotransmitters, 406t
Nonarteritic ischemic optic neuropathy
(NAION), phosphodiesterase
inhibitors and, 1792
Noncoding single nucleotide
polymorphisms, 148, 155
Noncompetitive inhibition, 96
Nondigestible alcohols, 1332
Nondigestible sugars, 1332
Non-gonococcal urethritis (NGU), 1842t
Non-Hodgkin’s lymphoma (NHL),
1755
drugs for, 1668t–1670t
Nonlinear pharmacokinetics, 33
Nonnucleoside reverse transcriptase
inhibitors, 1640–1644
delavirdine, 1642–1643
efavirenz, 1643–1644
etravirine, 1644
nevirapine, 1641–1642
Nonsedating antihistamines, 911, 920
Nonsense variation, 155t
Non-small cell lung cancer, 1735, 1736
Nonsteroidal anti-inflammatory drugs
(NSAIDs), 937, 959, 962–
977
absorption, 965
adverse effects and side effects of,
973–976, 973t
cardiovascular, 973t, 974
CNS, 973t
gastrointestinal, 973–974, 973t
hemodynamic, 974–975
on platelets, 973t
in pregnancy and lactation, 975
renal, 973t, 974–975
renovascular, 974–975
uterine, 973t
and analgesic nephropathy, 975
as analgesics, 971
and antidiuretic response to
vasopressin, 707–708
as antiinflammatory agents,
965–971
Nonsteroidal anti-inflammatory drugs
(NSAIDs) (Cont.):
antiplatelet effects of, 868
as antipyretics, 971
chemistry, 963
classification of
by chemical similarity, 962f
by COX isoform selectivity, 962f
by plasma pharmacokinetics of,
962f
clinical summary, 992–993
contraindications to, 975
COX2 selective, 962f, 990–992
COX-2 selective, classification of,
970t
cyclooxygenase inhibition, 963–964
diaryl heterocyclic, 990–992
classification of, 970t
distribution of, 965
drug interactions with, 976
elimination, 965
for fever, 961–962
history of, 959
hypersensitivity, 973t, 975
for inflammation, 965–971
and inhibition of eicosanoids, 941
and inhibition of prostaglandin
synthesis, 963–965
and low-dose aspirin, concomitant
therapy with, 976
mechanism of action of, 962,
963–965
for pain, 961
pharmacokinetics of
in children, 976–977
in elderly, 977
polymorphisms and response to,
159t
and prevention of Alzheimer’s
disease, 973
and renin release, 724
therapeutic uses of, 965–973
for cancer prevention,
972–973
in children, 976–977
for ulcers, 1319
ulcers and, 1320–1321
Nonsynonymous variant, 155t
Nonulcer dyspepsia, 1321
Norclomipramine, potencies at human
transporters for monamine
neurotransmitters, 406t
NORCURON (vecuronium bromide), 264t
Nordazepam, structure of, 459t
NORDETTE (ethinyl estradiol/
levonorgestrel), 1835t
2053
INDEX