DƯỢC LÍ Goodman & Gilman's The Pharmacological Basis of Therapeutics 12th, 2010

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SECTION VII
CHEMOTHERAPY OF MICROBIAL DISEASES
Table 49–3
Regimens for the Treatment of Malaria (Continued)
POTENTIAL ADVERSE
DRUG INDICATION ADULT DOSAGE PEDIATRIC DOSAGE a EFFECTS COMMENTS
Tetracycline P. falciparum Oral: 250 mg 25 mg/kg/d orally See doxycycline See doxycycline
(oral or IV) (chloroquine- 4 times divided 4 times
resistant areas) daily × 7 d daily × 7 d
P. vivax from IV: dosage same IV: dosage same as
chloroquine- as for oral for oral
resistant areas
(with quinine/
quinidine)
G6PD, glucose-6-phosphate dehydrogenase; IV, intravenous.
a
Pediatric dosage should never exceed adult dosage.
b
Extrapolated from chloroquine literature.
c
Mefloquine should not be used to treat P. falciparum infections acquired in the following areas: borders of Thailand with Burma (Myanmar) and Cambodia, western provinces of Cambodia, eastern
states of Burma (Myanmar), border between Burma and China, Laos along borders of Laos and Burma (and adjacent parts of Thailand-Cambodia border), and southern Vietnam due to resistant strains.
d
Quinine sulfate capsule manufactured in the U.S. is in a 324-mg dose; therefore, two capsules should be sufficient for adult dosing.
e
Nausea, vomiting, headache, tinnitus, deafness, dizziness, and visual disturbances.
f
Refer to quinine sulfate, package insert (Mutual Pharmaceutical Inc, Philadelphia, PA, Rev 08, November 2009).
g
Alternative dosing hypoglycemia optic neuritis regimen for quinidine gluconate (IV): 15 mg base/kg (24 mg salt/kg) loading dose IV infused over 4 h, followed by 7.5 mg base/kg (= 12 mg
salt/kg) infused over 4 h every 8 h, starting 8 h after the loading dose (see package insert); once parasite density <1% and patient can take oral medication, complete treatment with oral quinine,
dose as above Quinidine or quinine course = 7 d in SE Asia (3 d in Africa or South America)
h
Refer to quinidine gluconate, package insert (Eli Lilly Co, Indianapolis, IN, February 2002).
These regimens are based on published recommendations of the U.S. Centers for Disease Control and Prevention (CDC). Although current at the time of writing, these recommendations may
change over time. Up-to-date information should be obtained from the CDC website at www.cdc.gov/travel. Recommendations and available treatment differ among countries in the industrialized
world, developing world, and malaria-endemic regions; in the latter, some anti-malarial treatments may be available without prescription, but the most effective drugs usually are controlled by
governmental agencies.
From http://wwwnc.cdc.gov/travel/content/yellowbook/home-2010.aspx; accessed January 12, 2010.