DƯỢC LÍ Goodman & Gilman's The Pharmacological Basis of Therapeutics 12th, 2010

1387
Table 49–2
Regimens for the Prevention of Malaria in Non-immune Individuals
DRUG USAGE ADULT DOSE PEDIATRIC DOSE COMMENTS
Atovaquone/ Prophylaxis Adult tablets Pediatric tablets Begin 1-2 days before travel to
proguanil in all areas contain 250 mg (62.5 mg malarious areas. Take daily at
(MALARONE) atovaquone and atovaquone/25 mg the same time each day while
100 mg proguanil proguanil HCl). in the malarious area and for
hydrochloride. 5-8 kg: 1/2 7 days after leaving such areas.
1 adult tablet ped tab/day Contraindicated in persons with
orally, daily >8-10 kg: 3/4 severe renal impairment (creatinine
ped tab/day clearance <30 mL/minute).
>10-20 kg: 1 Atovaquone/proguanil should be
ped tab/day taken with food or a milky drink.
>20-30 kg: 2 Not recommended for prophylaxis
ped tab/day for children <5 kg, pregnant
>30-40 kg: 3 women, and women breastped
tab/day feeding infants weighing <5 kg.
>40 kg: 1 adult
tablet daily
Chloroquine Prophylaxis 300 mg base 5 mg/kg base Begin 1-2 weeks before travel to
phosphate only in (500 mg (8.3 mg/kg malarious areas. Take weekly on
(ARALEN areas with salt) orally, salt) orally, the same day of the week while in
and generic) chloroquine- once/week once/week, up the malarious area and for 4 weeks
sensitive to max adult dose after leaving such areas. May
malaria (300 mg base) exacerbate psoriasis.
Doxycycline Prophylaxis 100 mg orally, ≥8 years of age: Begin 1-2 days before travel to
in all areas daily 2 mg/kg up malarious areas. Take daily at
to adult dose the same time each day while
of 100 mg/day in the malarious area and for
4 weeks after leaving such
areas. Contraindicated in
children <8 years of age and
pregnant women.
Hydroxy- An alternative 310 mg base 5 mg/kg base Begin 1-2 weeks before travel to
chloroquine to chloroquine (400 mg (6.5 mg/kg malarious areas. Take weekly on the
sulfate for prophylaxis salt) orally, salt) orally, same day of the week while in the
(PLAQUENIL) only in areas once/week once/week, malarious area and for 4 weeks
with chloroquine- up to max adult after leaving such areas.
sensitive
dose
malaria
(310 mg base)
(Continued)