DƯỢC LÍ Goodman & Gilman's The Pharmacological Basis of Therapeutics 12th, 2010

Table 8–1
Responses of Effector Organs to Autonomic Nerve Impulses
ADRENERGIC
CHOLINERGIC
RECEPTOR PARASYMPATHETIC RECEPTOR
ORGAN SYSTEM SYMPATHETIC EFFECT a SUBTYPE b EFFECT a SUBTYPE b
Eye
Radial muscle, iris Contraction (mydriasis)++ α 1
Sphincter muscle, iris Contraction (miosis)+++ M 3
, M 2
Ciliary muscle Relaxation for far vision + β 2
Contraction for near M 3
, M 2
vision+++
Lacrimal glands Secretion+ α Secretion+++ M 3
, M 2
Heart c
Sinoatrial node a in heart rate++ β 1
> β 2
b in heart M 2
>> M 3
rate+++
Atria a in contractility and β 1
> β 2
b in contractility++ M 2
>> M 3
conduction velocity++
and shortened AP
duration
Atrioventricular a in automaticity and β 1
> β 2
b in conduction M 2
>> M 3
node conduction velocity++ velocity; AV block+++
His-Purkinje system a in automaticity and β 1
> β 2
Little effect M 2
>> M 3
conduction velocity
Ventricle a in contractility, β 1
> β 2
Slight b in M 2
>> M 3
conduction velocity,
contractility
automaticity and rate of
idioventricular
pacemakers+++
Blood Vessels
(Arteries and
arterioles) d
Coronary Constriction+; dilation e ++ α 1
, α 2
; β 2
No innervation h —
Skin and mucosa Constriction+++ α 1
, α 2
No innervation h —
Skeletal muscle Constriction; dilation e,f ++ α 1
; β 2
Dilation h (?) —
Cerebral Constriction (slight) α 1
No innervation h —
Pulmonary Constriction+; dilation α 1
; β 2
No innervation h —
Abdominal viscera Constriction +++; dilation + α 1
; β 2
No innervation h —
Salivary glands Constriction+++ α 1
, α 2
Dilation h ++ M 3
Renal Constriction++; dilation++ α 1
α 2
; β 1,
β 2
No innervation h
(Veins) d Constriction; dilation α 1
, α 2
; β 2
Endothelium — — a NO M 3
synthase h
Lung
Tracheal and bronchial Relaxation β 2
Contraction M 2
= M 3
smooth muscle
Bronchial glands b secretion, α 1
Stimulation M 2
, M 3
a secretion β 2
Stomach
Motility and tone b (usually) i + α 1
, α 2
, β 1
, β 2
a i +++ M 2
= M 3
Sphincters Contraction (usually)+ α 1
Relaxation (usually)+ M 3
, M 2
Secretion Inhibition α 2
Stimulation++ M 3
, M 2
(Continued)