DƯỢC LÍ Goodman & Gilman's The Pharmacological Basis of Therapeutics 12th, 2010

H 2 N
O
OH
GABA
(γ-amino butyric acid)
O
H
N
O
NH 2
MUSCIMOL
(GABA A agonist)
Cl
H 2 N
HO
C
BACLOFEN
(GABA B agonist)
O
H 2 N
OH
OH
S
HO O
Cl
2 – OH – SACLOFEN
(GABA B antagonist)
377
O
H 2 N
OH
GLYCINE
O
HO
CH 3 O
O
O
N O
O
CH 3
O
O C
O
C
O
O
H 3 C CH 2
BICUCULLINE
O
NH 2
OH
ASPARTIC ACID
(GABA A antagonists)
O
O
N
H
H 2 N
H
N
O
STRYCHNINE
(glycine antagonist)
PICROTOXIN
H 2 N
TAURINE
β -ALANINE
(Glycine receptor agonists)
H
O
S
O
OH
C
OH
O
CHAPTER 14
NEUROTRANSMISSION AND THE CENTRAL NERVOUS SYSTEM
HO
O
NH 2
O
GLUTAMIC ACID
OH
H 3 C
HN
O
OH
O
NMDA
(N–methyl–D–aspartate)
Figure 14–10. Amino acid transmitters and congeners.
OH
O
H 3 C
OH
AMPA
(α-amino–3–hydroxy–5–methyl–
4–isoxazolepropionic acid)
CH 2
H 3 C
NH 2
(Glutamate receptor subtype–specific agonists)
O
OH
HO
O
HO
O
KAINIC ACID
NH