DƯỢC LÍ Goodman & Gilman's The Pharmacological Basis of Therapeutics 12th, 2010

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R 2
N R 1
R 3
Compound R 1 R 2 R 3
Meperidine
CH 3 COCH 2 CH 3
O
Diphenoxylate
CH 2 CH 2
C
CN
COCH 2 CH 3
O
CHAPTER 18
Loperamide
Fentanyl
Sufentanil
CH 2 CH 2 C C N(CH 3 ) 2
OH
O
CH 2 CH 2 H
N CCH 2 CH 3
O
CH 2 CH 2
S
CH 2 OCH 3 N CCH 2 CH 3
O
O
OPIOIDS, ANALGESIA, AND PAIN MANAGEMENT
Alfentanil
Remifentanil
CH 2 CH 2 N N CH 2 CH 3
N N
CH 2 CH 2 C O CH 3
O
CCH 2 CH 3
CH 2 OCH 3 N
C O CH 3 N
O
CCH 2 CH 3
O
O
CH 3 CH 2
C C CH 2
O
CH 3
CH N
CH
CH 3
3
CH 3 CH 3
CH 3 CH 2 C O C CHCH 2 N
O CH 2
CH 3
Methadone
Propoxyphene
Figure 18–9. Chemical structures of piperidine and phenylpiperidine analgesics.