DƯỢC LÍ Goodman & Gilman's The Pharmacological Basis of Therapeutics 12th, 2010

Table 52–2
Structural Formulas of Selected Quinolones and Fluoroquinolones
R 1
8
R 7 X N 1
7
2
6
3
4
R 6 5
O
COOH
CONGENER R 1
R 6
R 7
X
Nalidixic acid —C 2
H 5
—H —CH 3
—N—
Cinoxacin —C 2
H 5
(Fused dioxolo ring)* —CH—
(N replaces C2)
Norfloxacin —C 2
H 5
—F
N NH
—CH—
Ciprofloxacin —F —CH—
N NH
Ofloxacin 8
—F —CH—
C O
N NH CH 3
N 1
CH 3
Sparfloxacin —F
(—NH 2
on C5)
N
CH 3
NH
F
C
CH 3
Fleroxacin —CH 2
—CH 2
—F —F
N
NH
CH 3
F
C
Pefloxacin —C 2
H 5
—F —CH—
N NH CH 3
Levofloxacin CH 3
—F
O
H
X
Garenoxacin —H
N
1
N
NH
CH 3
CH
O
C
N
1
OCHF 2
CH 3
NH
C
Gemifloxacin —F NH 2
—N—
N
N
OCH 3
∗
C
O
O