DƯỢC LÍ Goodman & Gilman's The Pharmacological Basis of Therapeutics 12th, 2010

1506
AC
AC I
AC II
AC III
AC
AC I
AC II
AC III
SECTION VII
CHEMOTHERAPY OF MICROBIAL DISEASES
R 1
HC
AC
H
HC
NHR 2 NH 2
NH 2
O
HO
H 3 C
NH 2
AC
O
NHCH 3
O
OH
OH
X
Gentamicin C
AC I
X
O
AD
AC II
AC III
NH 2
NHC 2 H 5
H
HC
HO
AC
H
HC
NH 2 NH 2
NH
O
2
OH
O
NH 2
CH 2 OH
O
O
NH 2
HO
OH AD
Tobramycin
AC AC I AC II AC III
XX X
NH 2 NH 2
NHC
NH 2
CH CH 2 CH 2
O
O
O
O
OH
HO
OH
O
OH
OH NH 2
AC
NH 2
HO
O
NHCH 3
H 3 C
OH
X
O
AD
P I
P II
X
X
X
OH
CH 2 OH
O
AC
NH 2
HO
OH
X
O
AD
Netilmicin
Amikacin
AC Acetylase AD Adenylase P Phosphorylase Protected from enzyme
Figure 54–1. Sites of activity of various plasmid-mediated enzymes capable of inactivating aminoglycosides. The red X indicates regions
of the molecules that are protected from the designated enzyme. In gentamicin C 1
, R 1
=R 2
=CH 3
; in gentamicin C 2
, R 1
=CH 3
, R 2
=H; in gentamicin
C 1a
, R 1
=R 2
=H. (Reproduced with permission from Moellering RC Jr. Microbiological considerations in the use of tobramycin
and related aninoglycosidic aminocyclitol antibiotics. MJA 1977;2S:4–8. Copyright 1977. The Medical Journal of Australia.)
X