DƯỢC LÍ Goodman & Gilman's The Pharmacological Basis of Therapeutics 12th, 2010

1992
INDEX
Acetohexamide, 1257t
Acetylation, 128t, 136–138
Acetylation deficiencies, isoniazid
reactions and, 77
Acetylcholine (ACh), 186–188, 186f,
222f
allosteric modulators and, 220
in autonomic system, 172, 177f
cardiovascular system and, 220–221
in CNS, 381–382
congeners, 222
in enteric nervous system, 175
enzymatic attack of, 240–241
GI tract and, 222
history of, 911
hydrolysis of, 219, 241f
muscarinic antagonists and, 225
muscarinic receptor and, 219–222
in neurotransmission, 185–186
in ocular surgery, 1788
pharmacological effects of, 220–222
as pruritogen, 1815
release of, 187–188, 199
therapeutic application of, 219, 224
and vasopressin secretion, 704
Acetylcholinesterase (AChE), 187, 188
acetylcholine hydrolysis, 219
gene coding of, 240
inhibitors, 239–242
structure of, 240–241, 240f, 241f
Acetyl-coenzyme A, 136–137
Acetylcysteine, as antidote, 86t
Acetylglyceryletherphosphorylcholine
(AGEPC), 952
N-Acetylprocainamide, 836t,
842–843
Acetylsalicylic acid, pharmacokinetics
of, 1809t
N-acetyltransferase, polymorphisms,
159t
ACh. See Acetylcholine (ACh)
AChE. See Acetylcholinesterase
(AChE)
Acid(s), organic, secretion in proximal
tubule, 676f
Acid-peptic disorders, 232, 1309–1321
Acitretin, 1809–1812, 1811t
Aclometasone dipropionate
cream, 1808t
ointment, 1808t
ACLOVATE (aclometasone dipropionate),
1225t, 1808t
Acne fulminans, dapsone for, 1823
Acne rosacea
treatment of, 1811, 1816, 1822
Acne vulgaris
treatment of, 1811–1812, 1811t,
1816–1817
Acrivastine, 921t
Acrodermatitis enteropathica, 103t
ACTH. See Adrenocorticotropic
hormone (ACTH)
Actinic cheilitis, 5-fluorouracil for,
1821
Actinic keratoses (AKs)
5-fluorouracil for, 1821
imiquimod for, 1823
photochemotherapy for,
1814t, 1815
sunscreens and, 1828
Actinic prurigo, thalidomide
for, 1824
Actinomycin D. See Dactinomycin
Actinomycosis, penicllin for, 1487
Action potential(s), cardiac, 815,
816–817
heterogeneity, 817–818, 818f
prolongation, 830
antiarrhythmic use of, 826f
Activated charcoal, 84, 85
Activated partial thromboplastin time
(aPTT), 853
ACTIVELLA (estradiol/norethindrone),
1839t
Active transport, 94–95, 94f
ACTOS (pioglitazone), 1845
ACULAR (ketorolac), 986
Acute coronary syndrome, 760
Acute lymphoblastic (lymphocytic,
lymphoid) leukemia (ALL),
1755
Acyclovir, 1593–1600, 1596t
chemistry of, 1593–1594
for cutaneous viral infections,
1818
for genital herpes, 1842t
mechanism of action of, 1594
for ophthalmic use, 1782
pharmacokinetics of, 1810t
Acyl-CoA:cholesterol acyltransferase,
878–881
inhibitors, 903
AD. See Alzheimer’s disease (AD)
ADALAT (nifedipine), 762t, 1847
Adalimumab, 994t, 1825t
for psoriasis, 1827
structural class, 1825t
Adapalene, 1809, 1810t
ADATOSIL 5000 (silicone oil), 1790
ADCIRCA (tadalafil), 758–759, 1792
Addiction. See also Drug abuse and
addiction
dopamine and, 357
opiate receptors and, 490
Additive interaction, 77
Adducin, 160t
Adefovir, 106t, 1614–1615
ADENOCARD (adenosine), 834
Adenosine, 833t, 834, 835t
antiarrhythmic use of, 824t, 827,
834–837
electrophysiological actions of, 829t
neurotransmitters and, 184
Adenosine A 1
receptor antagonists,
792–793
Adenosine monophosphate (AMP),
acetylcholine and, 221
Adenosine triphosphate (ATP)
active transport and, 94, 94f
in autonomic co-transmission, 213
as neurotransmitter, 172
storage, 197f
synthesis, 197f
ADHD. See Attention-deficit
hyperactivity disorder
(ADHD)
Adipocytes, beta adrenergic receptors
in, 204t
Administration of drugs. See Routes of
administration
Adrenal cortical cancer, drugs for,
1668t–1670t
Adrenal insufficiency, 1228–1231
Adrenal medulla, 174, 179t
in adrenergic transmission, 196
Adrenergic agents, centrally acting, as
antihypertensive agents,
774t
Adrenergic agonists
alpha (See Alpha-adrenergic
agonists)
beta (See Beta-adrenergic agonists)
classification of, 278f
Adrenergic antagonists, 304–330
alpha, 304–310
beta, 310–316
Adrenergic neuron blocking agents, as
antihypertensive agents, 774t
Adrenergic receptor antagonist(s),
mixed, as antihypertensive
agents, 774t, 780–781
Adrenergic receptors, 201–205, 204t
agonists and antagonists, 211–212
alpha, 201, 203t, 207–209
antipsychotics and, 427t