DƯỢC LÍ Goodman & Gilman's The Pharmacological Basis of Therapeutics 12th, 2010

Index
Information in figures and tables is denoted by f and t.
A
AADC. See Aromatic L-amino acid
decarboxylase (AADC)
Abacavir, 1626t, 1635–1637
antiviral activity of, 1635
drug interactions with, 1636–1637
mechanism of action of, 1635–1636
pharmacokinetics of, 1630t
polymorphisms and response to,
160t
sensitivity to, 164
Abarelix, structure of, 1764t
Abatacept, 994t
Abbreviations, in prescription order
writing, 1880–1881
ABC. See ATP-binding cassette (ABC)
proteins
ABCA1, 883–884
ABCB1 gene, 89
ABCC7 gene, 89
ABCG1, 883–884
Abciximab
antiplatelet effects, site of action,
868f
features, 871t
for myocardial ischemia, 752
Abdominal cramps, warfarin-induced,
864
Abetalipoproteinemia, 891
Abiraterone, 1767
effects on steroidogenesis, 1766f,
1767
Abortifacients, 952
Abortion, therapeutic, eicosanoids in,
952
ABREVA (docosanol), 1596t, 1818
Abrisentan, pharmacokinetics of,
1813t
Absence seizures, 588–589, 605
Absorption of drugs. See also
Bioavailability
ABC transporters in, 105t–106t, 107
binding and, 18f
bioavailability vs., 19
controlled-release preparations and,
21
definition of, 19
distribution and, 18f
excretion and, 18f
interaction of, 77
in intra-arterial administration, 22
in intramuscular administration, 20t,
22
in intrathecal administration, 22
in intravenous administration, 20t,
22
metabolism and, 18f
in oral administration, 20t, 21
percutaneous, 1803–1804, 1804f
mechanisms of, 1804–1805
poisoning and, 75
pulmonary, 22–23
rate of, 33
in subcutaneous administration, 20t,
22
Abuse, poisoning and, 80
Acamprosate, for alcoholism, 643
ACAT. See Acyl-CoA:cholesterol
acyltransferase
Accessory glands (ocular), 1773
Accommodative esotropia, autonomic
agents for, 1785t
ACCUPRIL (quinapril), 733, 797
ACCUTANE (isotretinoin), 1793, 1812
ACE. See Angiotensin converting
enzyme (ACE)
Acebutolol, 327
antiarrhythmic use of, 831–832
side effects of, 138t
structure of, 311f
Acenocoumarol, 860
structure of, 860f
ACEON (perindopril), 734
Acetaminophen, 982–984
adverse effects and side effects of,
983
antidote, 86t
compared to aspirin, 966t
COX isoform selectivity, 962f
distribution of, 983
dosage and administration of, 966t
hepatotoxicity of, 983
history of, 959
intoxication/poisoning, 983–984
manifestation of overdose
symptoms, 75–76, 75t
mechanism of action of, 982–983
metabolism of, 128t
pharmacokinetics of, 962f, 966t, 1809t
structure of, 982
therapeutic uses of, 966t, 983
toxicity pathways, 76f
Acetazolamide, 677–681, 679t, 1059
adverse effects, 680
mechanism of action of, 678–679
pharmacology of, 679t
structure of, 678, 679t
therapeutic uses of, 680–681