A Guide to the Russian Academy of Sciences - University of Texas ...

Subject of Research:
Genetic variability, differentiation and molecular evolution of human populations in
Siberia.
General Results 1993-1995:
Some Siberian native populations - Northern Selkups, Tundra and
Forest Nentsi, Altai-people, Evenks were involved in studies during
1993-1995. Results were obtained on genetic and demographic
aspects based on estimates of the population size, the degree of
admixture, migation flow, reproductive parameters, coefficient of
inbreeding, genealogical data etc., and on population genetic aspects
based on the studies of polymorphism with respect to blood groups,
serum proteins, izozymes and immunoglobulin markers (Gmsystem).
Molecular genetic investigations are being carried out on
immunoglobulin genes. Duplication of some immunoglobulin genes
(GPG2) was first discovered. It may be considered as compensatory
mechanism for previously founded deletions of genes IGHG1 and
IGHG4. Molecular genetic investigations are being carried out on
metachondrial DNA in some Siberian populations. Studies on
estimation of risk atherosclerosis and cardio-vascular diseases in
North Siberian natives was performed. A study of polymorphism
with respect to HLA antigenes (in Northern Selkups) was carried
out.
Participation in State and International Programs:
The Russian State Program "New Trends in Genetics": "The Creation of
Computer Data Bank of gene pool of the northwestern Siberian indigenous
populations for estimation of genetic potentials and
genetic-demographical processes".
The RFBR: "Complex study of gene pool of isolated populations of the
Siberian Russian Old Believers in comparison with panmixic Russian
population"
INTAS Project 93-0035: "Molecular diversity and evolution of the human
genome in the Northern Siberia".
Joined work on the basis of Agreement with the Laboratoire
d'Immunogenetigue Moleculaire, LIGM, Institut de Genetigue Moleculaire
(Montpellier, France) (1992-1996) in the field of immunogenetic studies
of indigenous populations of Siberia.
Joined International Project "Y chromosome variation in Native human
populations of Siberia" (Laboratory of Molecular Systematics and
Evolution, University of Arizona, Tucson, USA).
Subjects of Scientific Collaboration:
The studies of the Northern indigenous human populations (the
genetic-demographic, molecular-genetic and epidemiological aspects).
Molecular-genetic studies of human immunoglobulin genes (Gm system) in
the Northern indigenous populations, analysis of structure of human
immunoglobulin genes.
Population-genetic studies of genes controlling alcohol metabolizing
enzymes in the Northern indigenous human populations.
The studies of polymorphism of mitochondrial DNA in the Northern
indigenous human populations.
Y chromosome variation in Native human populations of Siberia.
1026