A Guide to the Russian Academy of Sciences - University of Texas ...

the translation apparatus of eukaryotes with special attention being paid to mRNP
particles (informosomes), to elongation factors EF-1 and EF-2 and to ribosomes.
Ovchinnikov, Lev P., C. Bio. S., Born in 1943. Corresponding member of the
Biochemistry, Biophysics, and Chemistry of Physiologically Active Compounds
Department (now the Physical Chemistry and Biology Department) of the Academy
since December 1987. Since 1974, he has been a senior researcher in the Protein
Biosynthesis Laboratory of the Protein Institute in Pushchino. In 1991, he was a
Deputy Director of the Protein Research Institute and head of the Regulation of
Protein Biosynthesis Laboratory of the institute whose main area of research
includes the organization and functioning of the translation apparatus of eukaryotes
with special attention being paid to mRNP particles (informosomes), to elongation
factors EF-1 and EF-2 and to ribosomes.
The Laboratory of Molecular Genetics under Nicholas I Matvienko, D. Bio. S.;
Daria P. Vorozheikina, C. Bio. S., researcher--studies the translation mechanism
components in themophile organisms utilizing gene engineering methods and
monoclonal antibodies. The regulation of gene activity at the transcription level and
the biological role of “anti-sense” RNA is being studied.
The Laboratory of Cell Biology under Vladimir I. Gelfand, D. Bio. S.; Eugene A.
Vainberg, C. Bio. S. and Fatima K. Gioeva, C. Bio. S. are researchers in this
laboratory which studies the cytoskeleton and mechanisms of cell motility. The
Laboratory of Peptide Chemistry under Iuri V. Mitin, D. Chem. S.; Nina P.
Zapevalova, C. Chem. S., Vera S. Grechishko, C. Chem. S., Viacheslav N.
Medvedkin, C. Chem. S., and Elena Iurii Gorbunova, C. Chem. S. are researchers
in the laboratory which develops methods of peptide synthesis, does synthesis of
biologically active peptides, does peptides modeling of the secondary structure of
proteins, and modifies proteins by methods of peptide chemistry.
The Laboratory of Protein Physics under Oleg B. Ptitsin, D. PM. S., was organized
in 1967 at the same time as the institute; Valentina E. Bychkova, C. PM. S, Aleksei
V. Finkelstein, C. PM. S, and Gennadi V. Semisotnov, C. PM. S. are researchers
who are developing the theory of protein three-dimensional structure and the
algorithm for the calculation of protein 3D-structure from its amino acid sequence,
are investigating the main stages of the process of protein self-organization in the
three dimensional structure from the completely structureless polypeptide chain, and
in protein engineering are creating and studying new proteins with a given threedimensional
structure.
The Laboratory of Protein Thermodynamics under Peter L. Privalov, D. PM. S.;
Sergei A. Potekhin, C. PM. S, Iuri V. Griko, C. PM. S, and Elizabeth I.
Tiktopulo, C. PM. S. are researchers whose work involves the elucidation of the
physical principles of folding and stabilizing of unique three-dimensional structures
of biological macromolecules, proteins and nucleic acids. The ultimate goal is the
creation of artificially stable protein structures.
The Laboratory of Protein Structure Analysis under Iuri N. Chirgadze, D. PM.
S., professor of molecular biology; Stanislav V. Nikonov, C. PM. S., Natalia A.
Nevskaia (aya), C. PM. S., and Evgenii V. Brazhnikov, C. PM. S, are researchers
studying the structural principles of the functioning of 3-D globular proteins at a
high resolution using X-ray structure determination of proteins in the crystalline
state.
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