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北京大学英语新闻网/Peking University News "2007 Theoretical Linguistics International Research Forum" Held at PKU PKU NEWS 2007--09--25 http://ennews.pku.edu.cn/news.php?s=190687193 Peking University, Beijing, Sep. 25th, 2007: "2007 Theoretical Linguistics International Research Forum", co-hosted by the Japanese Language and Culture Department of Foreign Languages College of PKU and Sino-Japan Theoretical Linguistics Research Institute, was successfully held at Peking University from September 1st to 2nd. Nearly 100 experts and scholars from China and Japan attended. Shen Li, representative of Sino-Japan Theoretical Linguistics Research Institute and associate professor of Doshisha University in Japan, and Professor Cheng Chaoxiang, President of Foreign Languages College of PKU addressed in the opening ceremony in the morning of September 1st. Lu Jianming, president of the World Chinese Language Teaching Institute and professor of Chinese Department of PKU expressed congratulations in the forum. Later, Professor Kageyama Taroo( from Kwansei Gakuin University, Japan), Professor Shen Jiaxuan(director of the Institute of Linguistics of Chinese Academy of Social Sciences), Professor MIHARA Kenichi( from Osaka University of Foreign Studies) gave the keynote report, respectively. The symposium entitled "How language reflects the world" was held in the afternoon. Kayoko Hideki (Kobe University), Hu Jianhua (CASS), Shen Li( Doshisha University), etc. made separate theme speech. Edited By : Liu Xiaohua Translated By : Chen Zhenxia Source : PKU News (Chinese) Related Topic : Related News : Related Feedback: 578
北京大学英语新闻网/Peking University News Fusion Peptide RK5 with Two Targets Provides Hope for the Development of Antitumor Drugs PKU NEWS 2007--09--24 http://ennews.pku.edu.cn/news.php?s=190620171 Peking University, Beijing, September 24, 2007: Gu Jun, professor from Department of Biochemistry and Molecular Biology of College of Life Sciences of Peking University, and Gao Jin from Molecular Pharmacy Division of Institution of Biophysics of Chinese Academy of Sciences, has completed their research study on Experimental Therapeutics, Molecular Targets, and Chemical Biology---Targeting Matrix Metalloproteinases and Endothelial Cells with a Fusion Peptide against Tumor, according to the recently released Cancer Research. The development of novel therapy for patients with tumor is still a challenge at the present time. The new design is a fusion peptide (RK5) with two targets as a novel agent against tumor. The fusion peptide RK5 containing the kringle 5 fragment of human plasminogen and a decapeptide (CTTHWGFTLC) was constructed and expressed in yeast. Matrix metalloproteinase (MMP) activity, proliferation, and migration of endothelial cells were examined in vitro, respectively. Angiogenesis, tumor growth, metastasis, and survival time were evaluated in vivo models. Administration of RK5 was delivered by both protein and gene approach. The results showed that RK5 inhibited the activity of MMP-9 and exhibited more inhibitory effects on proliferation and migration of endothelial cells than that of kringle 5 fragments and decapeptide individually. RK5 also inhibited angiogenesis, tumor growth, and metastasis and increased survival time of mice bearing tumor. In addition, the effectiveness of RK5 could be achieved by both protein and gene delivery. In conclusion, RK5 has potential to inhibit tumor growth and metastasis and to prolong survival time of animals bearing tumor. Therefore, fusion peptide RK5 with two targets provides a new design for the development of antitumor drugs and has potential for clinical application. The new design instills new ideas in the development of genetic engineering medicine, and has received worldwide attention. Edited By : Wang Yi Translated By : Wang Yi Source : PKU News (Chinese) 579
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指导教师刘乃勇本卷编辑
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