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Regional Basic Professional Training Course in Korea

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<strong>Regional</strong> <strong>Basic</strong> <strong>Professional</strong> <strong>Tra<strong>in</strong><strong>in</strong>g</strong> <strong>Course</strong> (BPTC) on Nuclear Safety<br />

more relevant <strong>in</strong>itiation events which eventually lead to cancer. Experiment shows<br />

that these mutational events <strong>in</strong> cells are <strong>in</strong>duced with a l<strong>in</strong>ear‐quadratic, (� 1 D+ α<br />

2 D 2 ), dependence on dose. Thus, cancer <strong>in</strong>duction data might be modelled us<strong>in</strong>g an<br />

<strong>in</strong>duction term for mutational events <strong>in</strong> cells and a cell kill<strong>in</strong>g term as <strong>in</strong> Eq. (2.3).<br />

This results <strong>in</strong> Eq. (2.4) [9]<br />

P = (α 0 + α 1D + α 2 D 2 )exp(‐β 1D‐� β 2D 2 ) (2.4)<br />

Here, the α terms describe defect <strong>in</strong>duction result<strong>in</strong>g from spontaneous, (α 0), 1‐hit and<br />

2‐hit components, while the terms describe 1‐ and 2‐hit components for cell death.<br />

Fig. (2.11) Typical survival and <strong>in</strong>cidence curves aga<strong>in</strong>st dose (Gy) <strong>in</strong> the range 0 – 20 Gy.<br />

(■) Cell survival us<strong>in</strong>g Eq. (2.3) and

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