30845 Suppl Giot.pdf - Giornale Italiano di Ortopedia e Traumatologia

in osteocondrale. I bioreattori possono essere considerati l’ultima
frontiera nella produzione degli scaffold. Condrociti autologhi sono
seminati su un substrato velocemente riassorbibile e posti in coltura
cellulare all’interno del bioreattore. Questo ultimo imprimendo
stimoli meccanici (pressione idrostatica) alla coltura stimola ed
accelera la produzione di matrice da parte delle cellule. Il prodotto
finale è quindi impiantato all’interno del difetto cartilagineo. Uno
studio clinico preliminare a breve termine ha dimostrato alla RM
un riempimento del 66%-100% del difetto con tessuto simile alla
cartilagine circostante nel 75% dei casi trattati 21 .
Ad oggi non è stato dimostrato quale sia la tecnica di riferimento
come alternativa all’ACI. Valide risposte ai diversi quesiti inerenti
la rigenerazione cartilaginea potranno essere dedotte soltanto alla
luce dei risultati di studi a lungo termine controllati randomizzati.
BIBLIOGraFIa
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