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30845 Suppl Giot.pdf - Giornale Italiano di Ortopedia e Traumatologia

30845 Suppl Giot.pdf - Giornale Italiano di Ortopedia e Traumatologia

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Durable Cure and reconstructive Success in Osteogenic Sarcoma<br />

Fig. 2. Fig. 3.<br />

clastic response may be a new effective treatment for osteogenic<br />

sarcoma. Furthermore, these fin<strong>di</strong>ngs support the potential for<br />

Fig. 4.<br />

S16<br />

development of an in<strong>di</strong>vidualized approach to the selection and<br />

administration of chemotherapeutic agents 12 .<br />

Survival of young patients whose tumors are very sensitive<br />

to chemotherapy exceeds 80%, and tra<strong>di</strong>tional reconstructive<br />

methods have a limited durability. There is a pressing need to<br />

improve prosthetic fixation. The newly developed Compress system<br />

is a novel strategy that holds great promise. Our experience<br />

includes 72 patients, inclu<strong>di</strong>ng 62 with > 2 years of follow up<br />

(2-10 years). Implant K-M survivorship is 89% at 5 years. This<br />

is better than we found for cemented or uncemented implants 13 .<br />

rEFErENCE<br />

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twenty-one. A review of one hundred and forty-five operative cases. J Bone<br />

Joint Surg Am 1970;52:411-23.<br />

2 Meyers PA, Heller G, Healey J, et al. Chemotherapy for nonmetastatic<br />

osteogenic sarcoma: the Memorial Sloan-Kettering experience. J Clin<br />

Oncol 1992;10:5-15.<br />

3 Rosen G, Marcove RC, Caparros B, et al. Primary osteogenic sarcoma:<br />

the rationale for preoperative chemotherapy and delayed surgery. Cancer<br />

1979;43:2163-77.<br />

4 MacEwen EG, Kurzman ID, Rosenthal RC, et al. Therapy for osteosarcoma<br />

in dogs with intravenous injection of liposome-encapsulated muramyl<br />

tripeptide. J Natl Cancer Inst 1989;21:81:935-8.<br />

5 Meyers PA, Schwartz CL, Krailo MD, et al. Osteosarcoma: the ad<strong>di</strong>tion of<br />

muramyl tripeptide to chemotherapy improves overall survival – a report<br />

from the Children’s oncology group. J Clin Oncol 2008;26:633-8.<br />

6 Lin PP, Pandey MK, Jin F, et al. Targeted mutation of p53 and Rb<br />

in mesenchymal cells of the limb bud produces sarcomas in mice.<br />

Carcinogenesis 2009;30:1789-95.<br />

7 Ulaner GA, Huang HY, Otero J, et al. Absence of a telomere maintenance<br />

mechanism as a favorable prognostic factor in patients with osteosarcoma.<br />

Cancer Res 2003;63:1759-63.<br />

8 Guo W, Gorlick R, Ladanyi M, et al. Expression of bone morphogenetic<br />

proteins and receptors in sarcomas. Clin Orthop Relat Res<br />

1999;(365):175-83.<br />

9 Yang R, Hoang BH, Kubo T, et al. Over-expression of parathyroid hormone<br />

type 1 receptor confers an aggressive phenotype in osteosarcoma. Int J<br />

Cancer 2007;121:943-54.<br />

10 Abdeen A, Chou AJ, Healey JH, et al. Correlation between clinical outcome<br />

and growth factor pathway expression in osteogenic sarcoma. Cancer<br />

2009;10.<br />

11 Mintz MB, Sowers R, Brown KM, et al. An expression signature<br />

classifies chemotherapy-resistant pe<strong>di</strong>atric osteosarcoma. Cancer Res<br />

2005;65:1748-54.<br />

12 Gorlick R, Anderson P, Andrulis I, et al. Biology of childhood osteogenic<br />

sarcoma and potential targets for therapeutic development: meeting<br />

summary. Clin Cancer Res 2003 November 15;9:5442-53.<br />

13 Farfalli GL, Boland PJ, Morris CD, et al. Early equivalence of uncemented<br />

press-fit and compress(R) femoral fixation. Clin Orthop Relat Res.<br />

2009;467:2792-9. [Epub ahead of print]

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