Molecular Biology of the Cell by Bruce Alberts, Alexander Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter by by Bruce Alberts, Alexander Johnson, Julian Lewis, David Morg

REFERENCES
1215
(A)
control
(A)
anterior
(B)
(B)
Delta-minus
posterior
(C)
(D)
(C)
Delta pulse
(D)
delay
Her7
Notch
Notch
delay
Her7
Figure Q21–3 Effects of Dpp expression on wing development in
Drosophila (Problem 21–16). (A) Normal Dpp expression. (B) Absence
of Dpp expression. (C) Additional anterior Dpp expression.
(D) Additional posterior Dpp expression. (From M. Zecca, K. Basler
and G. Struhl, Development 121:2265–2278, 1995. With permission
from The Company of Biologists.)
Delta
Delta
Figure Q21–2 Somite formation in zebrafish embryos (Problem 21–15).
(A) Wild-type embryos with normal somites. (B) Somite formation in
embryos lacking Delta. The bracket indicates normal-looking somites
where they initially form. (C) Somite formation in embryos lacking Delta,
but receiving a pulse of Delta expression at the time indicated by the
right-hand bracket. (D) Interactions among components of the oscillatory
clock in adjacent cells. (Adapted from C. Soza-Ried et al., Development
Figure 21-02
141:1780–1788, 2014. With permission from The Company of
Biologists.)
Problem 21-15
References
General
Carroll SB (2006) Endless Forms Most Beautiful: The New Science of
Evo Devo. New York: W.W. Norton & Co., Inc.
Gilbert SF (2013) Developmental Biology, 10th ed. Sunderland, MA:
Sinauer Associates, Inc.
Wolpert L & Tickle C (2010) Principles of Development, 3rd ed. Oxford,
UK: Oxford University Press.
Overview of Development
Gurdon JB (2013) The egg and the nucleus: a battle for supremacy
(Nobel Lecture). Angew. Chem. Int. Ed. Engl. 52, 13890–13899.
Istrail S & Davidson EH (2005) Logic functions of the genomic cisregulatory
code. Proc. Natl Acad. Sci. USA 102, 4954–4959.
Levine M (2010) Transcriptional enhancers in animal development and
evolution. Curr. Biol. 20, R754–R763.
Lewis J (2008) From signals to patterns: space, time, and mathematics
in developmental biology.Science 322, 399–403.
Meinhardt H & Gierer A (2000) Pattern formation by local self-activation
and lateral inhibition. Bioessays 22, 753–760.
Rogers KW & Schier AF (2011) Morphogen gradients: from generation
to interpretation. Annu. Rev. Cell Dev. Biol. 27, 377–407.
Shubin N, Tabin C & Carroll S (2009) Deep homology and the origins of
evolutionary novelty. Nature 457, 818–823.
part of the wing, a large mass of wing tissue composed of
normal-looking cells is produced at the site of Dpp expression
(Figure Q21–3C and D). Does Dpp stimulate cell division,
cell growth, or both? How can you tell?
21–17 The highly branched structures of neurons would
seem to make it almost inevitable that they should make
unproductive synapses with themselves, yet they manage
to avoid this outcome very effectively. How is this accomplished
in vertebrates?
Figure 21-03
Problem 21-16
Mechanisms of Pattern Formation
Andrey G & Duboule D (2014) SnapShot: Hox gene regulation. Cell
156, 856–856.e1.
Baker NE (2011) Proximodistal patterning in the Drosophila leg: models
and mutations. Genetics 187, 1003–1010.
Chan YF, Marks ME, Jones FC et al. (2010) Adaptive evolution of pelvic
reduction in sticklebacks by recurrent deletion of a Pitx1 enhancer.
Science 327, 302–305.
Davis RL, Weintraub H & Lassar AB (1987) Expression of a single
transfected cDNA converts fibroblasts to myoblasts. Cell
51, 987–1000.
De Robertis EM (2006) Spemann’s organizer and self-regulation in
amphibian embryos. Nat. Rev. Mol. Cell Biol. 4, 296–302.
DiNardo S, Heemskerk J, Dougan S & O’Farrrell PH (1994) The making
of a maggot: patterning the Drosophila embryonic epidermis. Curr.
Opin. Genet. Dev. 4, 529–534.
Driever W & Nüsslein-Volhard C (1988) A gradient of bicoid protein in
Drosophila embryos. Cell 54, 83–93.
Fowlkes CC, Luengo CL, Keränen VE et al. (2008) A quantitative
spatiotemporal atlas of gene expression in the Drosophila
blastoderm. Cell 133, 364–74.
Furman DP & Bukharina TA (2008) How Drosophila Melanogaster forms
its mechanoreceptors. Curr. Genomics 9, 312–323.