Molecular Biology of the Cell by Bruce Alberts, Alexander Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter by by Bruce Alberts, Alexander Johnson, Julian Lewis, David Morg

Index I:47
specimen preparation
electron microscopy 555–556, 559
light microscopy 535–536
speckles, nuclear (interchromatin granule
clusters) 213, 331–333
speckles, tubulin 991F
spectinomycin 351F
spectral karyotyping 181F
spectrin 591, 592F, 905, 911F, 912–913
spermatozoa
as centrosome source 987
elimination of mitochondria from 807
localization of mitochondria 755, 756F
membrane domains 590, 591F
see also fertilization
sphingolipids 567–568, 573, 575
sphingomyelin 567, 571T, 572F, 574–575,
690
sphingosine 690
spin labels 569–570
spinal cord
development 1170F, 1186,
1199–1200, 1202, 1203F, 1209F
injury 1251
spinal muscular atrophy 324
spindle see central spindle; mitotic
spindles
spindle assembly checkpoints 993–994
spindle pole body 557F, 930
Spirulina platensis 778F
spleen
antigen removal 1311
cells, transplanted in mice 1193
erythrocyte removal 1244
hematopoietic stem cells in 1244
lymphocyte accumulation 1031, 1055
lymphocyte activation 1308–1309,
1311
spliceosomes
catalysis 321, 324
GFP-tagged 544F
intron sequence ambiguities 416
role 319–320
splicing enhancers 322
Spo11 protein 282–285
SR proteins 322, 323F, 326
Src protein kinases 117, 118F, 155–156,
157F, 578
binding via SH2 domains 852
as cytoplasmic tyrosine kinases 862,
1080, 1336
Lck protein as 1331–1332
regulation 155–156
viral cancers and 1265
SREBP (sterol response element binding
protein) 656F
SRP-like pathway 665F
SRP receptor 673–674, 678F
SRPs (signal-recognition particles)
673–674, 675F, 677–680
and the nucleolus 330
SSB (single-strand binding) proteins 246,
247–248F, 253, 256F
staining
cell cycle stages 966
electron microscopy 555–556
Gram-positive and Gram-negative
610F, 1267F
light microscopy 529, 535, 536F
white blood cells 1240F
see also fluorescent dyes
standard free energy changes, ∆G°
comparing reactions 61–62, 765
deriving equilibrium constants 62–63,
63T, 139F
phosphate bond breakage 78, 79F
viability of reactions 71–72
standard redox potentials 765
Staphylococcus (S. aureus)
antibiotic-resistant (MRSA) 1276
as opportunists 1276
Staphylococcus spp. as Gram-positive
1267F
starch 80–81, 785–786
starfish eggs 839F
start codons 347–348
start-transfer signals 678–680, 681F
Start transition 965, 966F, 968–970, 972,
1014
STAT proteins (signal transducers and
activators of transcription) 863
stathmin (Op18) 933, 935, 959
statins 733
statistical methods in biology 524–525
steady-state concentrations 513F, 514
steady-state kinetics 142
steady states
actin filament growth 901, 902, 904
bistabililty 518–520
negative feedback effects 516
protein-promoter complexes 511
stable and unstable 519
time to attain 512, 514, 516
stearic acid 98
STED (stimulated emission depletion
microscopy) 551–552
Steel/SCF protein 1187, 1244
stem-cell niche 1222
stem cells
in artificial replacement 1249–1250
asymmetric cell division idea 1222,
1223F
blood cell formation from 1239–1247
cancer stem-cells 1120–1122, 1124
defining properties 1219, 1220F
epidermal stem cells 1225–1226
in epithelial tissues 1217–1227
guided generation of cells and organs
1266–1267
hematopoietic 1239, 1242–1243,
1308
independent-choice theory 1222,
1223F
in intestinal crypts 1122, 1124,
1219–1220, 1224
mesenchymal 1229
multipotent 1219F, 1220–1221, 1222F,
1229, 1239, 1242–1244
mutation risk 1243
myoblasts persisting as 1234
neoblasts resembling 1248–1249
neural stem cells 1201F, 1250, 1251F
organoids from 1223
restricted possibilities 1251
therapeutic use 1249–1251
types 1220
stem cells, embryonic
in drug discovery 1258–1259
guided generation of cells and organs
1266–1267
production and pluripotency 1253
transcription network 399F, 1254
Page numbers with an F refer to a figure; page numbers with a T refer to a table.
stem cells, pluripotent
induced pluripotency 398, 401,
1254–1259
through reprogramming 398
stem-loop structures, RNA 414, 423F,
427F, 435
stereocilia 890, 892, 924, 1189–1190
“steric zipper” 131F
steroids 99, 875–876
brassinosteroids 881
sterols, cholesterol as 568
sticklebacks 1174–1175
“sticky ends” 465F
stochastic effects 523–524
stomach cancer 1093, 1110F, 1120,
1129F, 1132, 1265, 1277
stop codons 348–349, 350
nonsense-mediated mRNA decay
327F, 352–353
premature 418
relative scarcity in ORFs 482
tumor suppressor gene mutations
1110F
stop-transfer sequences 663, 679–680,
681F
STORM (stochastic optical reconstruction
microscopy) 552, 553F
strand-directed mismatch repair 244T,
245, 250–251
strand exchange (strand invasion), in
homologous recombination
264F, 278–282, 283F, 284
streptavidin 538F, 549F
Streptococcus (S. pneumoniae)
as an opportunist 1276
as Gram-positive 1267F
transformation with alien DNA 174F
streptogramin 351F
Streptomyces spp. 1293
stress
MAP kinase response 857
NFκB signaling and 873–874
in plants 881
survival by cancer cells 1099, 1103,
1115–1116, 1133
stress fibers 891, 911, 923, 955–957,
958F, 996
stress granules 427–428
striated muscle 891, 918
stripes, Drosophila embryo 393–395
strokes, apoptosis and 1031–1032
stroma, basal lamina 1069, 1100–1101,
1228
stroma, chloroplasts 658, 665, 782
stromal cell contact, stem cells 1244
STRs (short tandem repeats) 476
strychnine 629
subclones
in adenomatous polyps 1123
in cancer 1096, 1097F, 1118–1119,
1123
substrate affinity, K m as measuring 143
substrates
direction into reaction pathways 58,
59F
in enzymes catalysis 51, 57, 140–141
see also enzyme-substrate complexes
succinate dehydrogenase (Complex II)
767–768F, 772–773, 775
succinyl-CoA 107
sucrose 784, 786